University of Trieste, Chemical and Pharmaceutical Sc. Dept., Via L. Giorgieri 1, 34127 Trieste, Italy.
CSIRO Manufacturing, Clayton, VIC 3168, Australia.
Chem Commun (Camb). 2020 Mar 10;56(20):3015-3018. doi: 10.1039/c9cc09947f.
The uncapped tripeptide DPhe-Phe-Leu acts as self-assembly template to yield supramolecular hydrogel biomaterials. As an example, self-assembling DPhe-Phe-Leu-Asp-Val contains the LDV bioadhesive motif for β1 integrin activation. Hydrogels made of the two peptides successfully mimic fibronectin of the extracellular matrix and lead to high cell viability, adhesion, and spreading.
未封闭的三肽 DPhe-Phe-Leu 可作为自组装模板生成超分子水凝胶生物材料。例如，自组装的 DPhe-Phe-Leu-Asp-Val 包含用于 β1 整合素激活的 LDV 生物黏附基序。由这两种肽制成的水凝胶成功模拟了细胞外基质中的纤维连接蛋白，从而导致高细胞活力、黏附和扩展。
