Wellcome-Wolfson Institute for Experimental Medicine, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, 97 Lisburn Road, Belfast BT9 7BL, UK.
Medical Biology Centre, School of Nursing and Midwifery, Queen's University Belfast, 97 Lisburn Road, Belfast BT9 7BL, UK.
Molecules. 2023 Jun 7;28(12):4616. doi: 10.3390/molecules28124616.
To create functional tissue engineering scaffolds, biomaterials should mimic the native extracellular matrix of the tissue to be regenerated. Simultaneously, the survival and functionality of stem cells should also be enhanced to promote tissue organisation and repair. Hydrogels, but in particular, peptide hydrogels, are an emerging class of biocompatible scaffolds which act as promising self-assembling biomaterials for tissue engineering and regenerative therapies, ranging from articular cartilage regeneration at joint defects, to regenerative spinal cord injury following trauma. To enhance hydrogel biocompatibility, it has become imperative to consider the native microenvironment of the site for regeneration, where the use of functionalised hydrogels with extracellular matrix adhesion motifs has become a novel, emerging theme. In this review, we will introduce hydrogels in the context of tissue engineering, provide insight into the complexity of the extracellular matrix, investigate specific adhesion motifs that have been used to generate functionalised hydrogels and outline their potential applications in a regenerative medicine setting. It is anticipated that by conducting this review, we will provide greater insight into functionalised hydrogels, which may help translate their use towards therapeutic roles.
为了构建功能性组织工程支架，生物材料应模仿待再生组织的天然细胞外基质。同时，还应增强干细胞的存活和功能，以促进组织的组织和修复。水凝胶，特别是肽水凝胶，是一类新兴的生物相容性支架，作为组织工程和再生疗法有前途的自组装生物材料，从关节缺陷处的关节软骨再生，到创伤后再生性脊髓损伤。为了提高水凝胶的生物相容性，必须考虑到再生部位的天然微环境，使用具有细胞外基质粘附基序的功能化水凝胶已成为一种新颖的新兴主题。在这篇综述中，我们将介绍组织工程中的水凝胶，深入了解细胞外基质的复杂性，研究已用于生成功能化水凝胶的特定粘附基序，并概述它们在再生医学环境中的潜在应用。预计通过进行这项研究，我们将对功能化水凝胶有更深入的了解，这可能有助于将它们的用途转化为治疗用途。
