School of Public Health, Hangzhou Medical College, Hangzhou, Zhejiang, China.
Department of Science and Education, The Second Affiliated Hospital of Xiamen Medical College, Xiamen, China.
Oral Oncol. 2020 Apr;103:104587. doi: 10.1016/j.oraloncology.2020.104587. Epub 2020 Feb 9.
The relationship between dietary inflammatory index (DII) and upper aerodigestive tract (UADT) cancer risk have been investigated in a growing number of epidemiological studies. However, their findings were inconsistent, and no systematic review or meta-analysis has been conducted up to now. This meta-analysis was carried out to examine potential dose-response relationship between DII score and UADT cancer risk.
A systematic search was conducted for relevant studies in PubMed and Web of Science up to March 28, 2019. Categorical meta-analysis as well as linear and non-linear dose-response meta-analysis were performed to evaluate association between DII and UADT cancer risk.
Nine case-control studies with a total of 4138 cases and 15,326 healthy controls were eligible in the present meta-analysis. The pooled odds ratios (ORs) of UADT cancer risk were 2.07 [95% confidence interval (CI): 1.82, 2.35] for the highest DII score compared with the lowest and 1.53 (95% CI: 1.39, 1.69) for higher DII score compared with lower score, respectively. Furthermore, a one-unit increment in DII score was associated with an increased risk of 18% for UADT cancers (OR: 1.18; 95% CI: 1.15, 1.21). An upward trend towards a positive association between elevated DII score and UADT cancer risk was also observed in non-linear dose-response meta-analysis.
The present meta-analysis provides evidence of highly pro-inflammatory diets that might increase risk of UADT cancers. Therefore, reducing pro-inflammatory components in diets should be considered to prevent and control UADT cancers.
越来越多的流行病学研究调查了饮食炎症指数（DII）与上呼吸消化道（UADT）癌症风险之间的关系。然而，他们的研究结果并不一致，到目前为止，还没有进行系统的综述或荟萃分析。本荟萃分析旨在研究 DII 评分与 UADT 癌症风险之间的潜在剂量反应关系。
系统检索了截至 2019 年 3 月 28 日PubMed 和 Web of Science 中相关的研究。采用分类荟萃分析以及线性和非线性剂量反应荟萃分析来评估 DII 与 UADT 癌症风险之间的关联。
本荟萃分析纳入了 9 项病例对照研究，共包括 4138 例病例和 15326 例健康对照。与最低 DII 评分相比，最高 DII 评分的 UADT 癌症风险的合并比值比（OR）为 2.07（95%置信区间[CI]：1.82，2.35），而与较低 DII 评分相比，较高 DII 评分的 UADT 癌症风险的合并 OR 为 1.53（95% CI：1.39，1.69）。此外，DII 评分每增加一个单位，UADT 癌症的风险增加 18%（OR：1.18；95% CI：1.15，1.21）。在非线性剂量反应荟萃分析中，也观察到 DII 评分升高与 UADT 癌症风险之间呈正相关的上升趋势。
本荟萃分析提供了证据表明，高度促炎饮食可能会增加 UADT 癌症的风险。因此，应考虑减少饮食中的促炎成分，以预防和控制 UADT 癌症。
