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饮食炎症指数（DII）与上消化道癌症风险之间关联的Meta分析。

Meta-analysis of the association between dietary inflammatory index (DII) and upper aerodigestive tract cancer risk.

作者信息

Hua Rongyu, Liang Guanmian, Yang Fangying

机构信息

School of Nursing, Zhejiang Chinese Medical University.

Department of Nursing, Institute of Cancer and Basic Medicine (ICBM), Chinese Academy of Sciences & Cancer Hospital of the University of Chinese Academy of Sciences & Zhejiang Cancer Hospital, Hangzhou 310022, China.

出版信息

Medicine (Baltimore). 2020 Apr;99(17):e19879. doi: 10.1097/MD.0000000000019879.

DOI:10.1097/MD.0000000000019879
PMID:32332658
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7220683/
Abstract

BACKGROUND

Epidemiological studies have reported an inconsistent relationship between dietary inflammatory index (DII) and upper aerodigestive tract (UADT) cancer risk. However, no systematic review or meta-analysis has been reported up to now. To quantify the association between DII and UADT cancer risk, we performed this meta-analysis.

METHODS

The PubMed, EMBASE, Web of Science and Cochrane Library database were searched for relevant studies from inception December 2018. All case-control studies investigating the association between DII and UADT cancer risk were selected.

RESULTS

A total of 9 case-control studies were identified, involving 13,714 participants. The adjusted pooled OR of UADT cancer for the highest (the most pro-inflammatory diet) vs lowest (the most anti-inflammatory diet) DII categories were 2.27 (95% CI: 1.89-2.73). Subgroup analysis showed that individuals with the highest category of DII score were independently associated with esophagus cancer (OR = 2.53, 95% CI: 1.74-3.68), oral cavity cancer (OR = 2.23, 95% CI: 1.73-2.86), pharyngeal cancer (OR = 2.02, 95% CI: 1.54-2.64), and laryngeal cancer (OR = 2.05, 95% CI: 0.85-4.93).

CONCLUSION

This meta-analysis suggested that the most pro-inflammatory diets (the highest DII scores) are associated with increased UADT cancer risk. However, the association between DII and laryngeal cancer risk need to be further investigated.

摘要

背景

流行病学研究报告了饮食炎症指数（DII）与上消化道（UADT）癌症风险之间的关系并不一致。然而，目前尚未有系统评价或荟萃分析的报道。为了量化DII与UADT癌症风险之间的关联，我们进行了这项荟萃分析。

方法

检索PubMed、EMBASE、Web of Science和Cochrane图书馆数据库，以查找自2018年12月开始的相关研究。选择所有调查DII与UADT癌症风险之间关联的病例对照研究。

结果

共确定了9项病例对照研究，涉及13714名参与者。最高（最促炎饮食）与最低（最抗炎饮食）DII类别下UADT癌症的调整后合并比值比为2.27（95%CI：1.89-2.73）。亚组分析表明，DII评分最高类别的个体与食管癌（OR = 2.53，95%CI：1.74-3.68）、口腔癌（OR = 2.23，95%CI：1.73-2.86）、咽癌（OR = 2.02，95%CI：1.54-2.64）和喉癌（OR = 2.05，95%CI：0.85-4.93）独立相关。

结论

这项荟萃分析表明，最促炎的饮食（DII评分最高）与UADT癌症风险增加相关。然而，DII与喉癌风险之间的关联需要进一步研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec2e/7220683/aa220ed61846/medi-99-e19879-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec2e/7220683/63256221dca1/medi-99-e19879-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec2e/7220683/964e6dd6eddf/medi-99-e19879-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec2e/7220683/933a6873e665/medi-99-e19879-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec2e/7220683/c6884b7d6d99/medi-99-e19879-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec2e/7220683/aa220ed61846/medi-99-e19879-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec2e/7220683/63256221dca1/medi-99-e19879-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec2e/7220683/964e6dd6eddf/medi-99-e19879-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec2e/7220683/933a6873e665/medi-99-e19879-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec2e/7220683/c6884b7d6d99/medi-99-e19879-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec2e/7220683/aa220ed61846/medi-99-e19879-g006.jpg

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