Exposure to melamine and its derivatives in childcare facilities.

Melamine (MEL) and its derivatives are widely used in many consumer products, including furniture, kitchenware, and plastics. However, very limited knowledge exists on human exposure to MEL and its derivatives, especially in the indoor environment. Here, we determined the occurrence and distribution of 11 MEL derivatives in childcare facilities and estimated children's exposure through dust ingestion and dermal absorption. We analyzed dust and samples of nap mats, a commonly used item in many childcares, from eight facilities located in the United States. Eight MEL-based compounds were detected in dust, and total MEL concentrations ranged from 429 to 117,000 ng/g. The most abundant compounds found in the dust samples were MEL, cyanuric acid (CYA), ammeline (AMN), and ammelide (AMD), with median concentrations of 1620, 585, 1060, and 299 ng/g, respectively. MEL, CYA, AMN and 2,4,6-tris[bis(methoxymethyl)amino]-1,3,5-triazine (TBMMAT) were also detected in nap mats with median concentrations of 45.6, 19.8, 1510 and 2.5 ng/g, respectively. ΣMEL concentrations in mat covers (median 709 ng/g) were significantly higher than those in mat foam (median 15.1 ng/g). Estimated daily intakes (EDIs) of MEL and its derivatives via dust ingestion were two orders of magnitude higher than the EDIs through dermal absorption, but both were below the established tolerable daily intake levels. This is the first report on exposure to MEL and its derivatives in the childcare environment.