Roche Jeanne, Câmara-Costa Hugo, Roulin Jean-Luc, Chevignard Mathilde, Frappaz Didier, Guichardet Karine, Benkhaled Ouarda, Kerrouche Bernadette, Prodhomme Julie, Kieffer-Renaux Virginie, Le Gall Didier, Fournet Nathalie, Roy Arnaud
Laboratory of Psychology Pays de la Loire, EA4638, UBL, Angers University, Angers, France.
SMAEC, Resource Centre for Children, Adolescents, Young Adults with Acquired Neurological Injury, Miribel, France.
Brain Inj. 2020 Mar 20;34(4):583-590. doi: 10.1080/02699052.2020.1725982. Epub 2020 Feb 12.
: Childhood brain tumors (BTs) and their treatment often negatively affect development of executive functions. Previous studies have reported executive functions deficits, particularly through questionnaires of daily life. This study aimed to assess executive functioning in everyday life following pediatric BT, in a larger and more histologically diverse sample than previously, and to study clinical and demographic factors influencing outcome.: Assessment of executive functioning using parent ratings of the Behavior Rating Inventory of Executive Function (BRIEF), in a large sample of children treated for various BT (n = 153). Clinical and demographic factors were: age at diagnostic, age at assessment, parental education level, radiation therapy.: Significant difficulties were found in the 3 composite indices and in the majority of the BRIEF subscales. The highest level of difficulties was observed in the Working Memory subscale. Older age at assessment and younger age at diagnosis were significantly associated with higher levels of parent-reported difficulties, particularly for metacognition.: Parents of children treated for BT report widespread and persistent deficits in executive functions that negatively affect their everyday functioning. Including analysis of all clinical scales and composite indices allows a more comprehensive approach and enables to specify the patients' executive profile.
儿童脑肿瘤(BTs)及其治疗常常对执行功能的发展产生负面影响。先前的研究报告了执行功能缺陷,特别是通过日常生活问卷得出的结果。本研究旨在评估小儿脑肿瘤治疗后日常生活中的执行功能,样本量比之前更大且组织学上更多样化,并研究影响结果的临床和人口统计学因素。:使用执行功能行为评定量表(BRIEF)的家长评定对大量接受各种脑肿瘤治疗的儿童(n = 153)进行执行功能评估。临床和人口统计学因素包括:诊断时年龄、评估时年龄、父母教育水平、放射治疗。:在3个综合指标和大多数BRIEF分量表中发现了显著困难。在工作记忆分量表中观察到的困难程度最高。评估时年龄较大和诊断时年龄较小与家长报告的较高困难水平显著相关,尤其是在元认知方面。:接受脑肿瘤治疗的儿童的家长报告称,执行功能存在广泛且持续的缺陷,这对他们的日常生活功能产生了负面影响。对所有临床量表和综合指标进行分析可以采用更全面的方法,并能够明确患者的执行功能概况。