Department of Legal Medicine and Toxicology, School of Medicine, Granada University, Granada, Spain.
Department of Pediatrics, Reina Sofía University Hospital, University of Córdoba, Instituto Maimónides de Investigación Biomédica (IMIBIC), Córdoba, Spain.
Ital J Pediatr. 2020 Feb 12;46(1):19. doi: 10.1186/s13052-020-0780-1.
The pathophysiological etiologies related with the development of Autism Spectrum Disorders (ASD) remain controversial. Different authors have studied neurotoxins such as mercury (Hg) and their relationship with ADS. The objective of this study was to assess the levels of Hg in hair in a group of ASD children (chronic exposure) and in urinary excretion (acute exposure), in comparison to a healthy group.
A case-control study was conducted in Spanish children. We compared 54 ASD children (aged 2-6) with no other associated pathology to a normally-developing control group (54 subjects).
There were no differences in urine (p:0.631) and hair (p:1.000) samples percentages below the limits of detection between the control and the ASD groups, and also between patients in the regression ASD subgroup (AMR) (p:0.08) and the non-regression ASD subgroup (ANMR) (p:0.705). When the analysis was adjusted for age and sex, the differences between Hg levels maintained not significant. There were no correlations between Hg concentrations in the ASD group as a whole (p: 0.739), or when they were subdivided into ASD-AMR (p: 0.739) and ASD-ANMR (p: 0.363).
The present study shows no evidence in our geographical area to support an association between mercury neurotoxicity and the etiopathogenesis of ASD.
自闭症谱系障碍（ASD）发展相关的病理生理学病因仍存在争议。不同的作者研究了神经毒素，如汞（Hg）及其与 ADS 的关系。本研究的目的是评估一组 ASD 儿童（慢性暴露）的头发中汞水平和尿液排泄（急性暴露），并与健康组进行比较。
进行了一项西班牙儿童的病例对照研究。我们将 54 名无其他相关病理的 ASD 儿童（年龄 2-6 岁）与正常发育的对照组（54 名受试者）进行了比较。
对照组和 ASD 组的尿液（p：0.631）和头发（p：1.000）样本中低于检测限的百分比没有差异，也没有在回归 ASD 亚组（AMR）（p：0.08）和非回归 ASD 亚组（ANMR）（p：0.705）的患者之间存在差异。当按年龄和性别调整分析时，Hg 水平之间的差异仍然不显著。整个 ASD 组（p：0.739）或分为 ASD-AMR（p：0.739）和 ASD-ANMR（p：0.363）时，Hg 浓度之间均无相关性。
本研究在我们的地理区域没有证据支持汞神经毒性与 ASD 的病因发病机制之间存在关联。
