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加拿大安大略省的医疗协助死亡的早期经验:一项队列研究。

Early experience with medical assistance in dying in Ontario, Canada: a cohort study.

机构信息

Division of Palliative Care (Downar), Department of Medicine, Faculty of Medicine, University of Ottawa; Department of Critical Care (Downar), The Ottawa Hospital, Ottawa, Ont.; Interdepartmental Division of Critical Care Medicine (Fowler), Faculty of Medicine; Institute of Health Policy, Management and Evaluation (Fowler), Dalla Lana School of Public Health, University of Toronto; Office of the Chief Coroner (Halko), Ministry of the Solicitor General, Government of Ontario, Toronto, Ont.; Department of Public Health Sciences (Davenport Huyer), School of Medicine, Queen's University, Kingston, Ont.; Sunnybrook Research Institute and Department of Critical Care Medicine (Hill), Sunnybrook Hospital; Division of Clinical Public Health, Institute of Health Policy, Management and Evaluation, and Joint Centre for Bioethics (Gibson), Dalla Lana School of Public Health, University of Toronto, Toronto, Ont.

出版信息

CMAJ. 2020 Feb 24;192(8):E173-E181. doi: 10.1503/cmaj.200016. Epub 2020 Feb 11.

Abstract

BACKGROUND

Medical assistance in dying (MAiD) was legalized across Canada in June 2016. Some have expressed concern that patient requests for MAiD might be driven by poor access to palliative care and that social and economic vulnerability of patients may influence access to or receipt of MAiD. To examine these concerns, we describe Ontario's early experience with MAiD and compare MAiD decedents with the general population of decedents in Ontario.

METHODS

We conducted a retrospective cohort study comparing all MAiD-related deaths with all deaths in Ontario, Canada, between June 7, 2016, and Oct. 31, 2018. Clinical and demographic characteristics were collected for all MAiD decedents and compared with those of all Ontario decedents when possible. We used logistic regression analyses to describe the association of demographic and clinical factors with receipt of MAiD.

RESULTS

A total of 2241 patients (50.2% women) were included in the MAiD cohort, and 186 814 in the general Ontario decedent cohort. Recipients of MAiD reported both physical (99.5%) and psychologic suffering (96.4%) before the procedure. In 74.4% of cases, palliative care providers were involved in the patient's care at the time of the MAiD request. The statutory 10-day reflection period was shortened for 26.6% of people. Compared with all Ontario decedents, MAiD recipients were younger (mean 74.4 v. 77.0 yr, standardized difference 0.18);, more likely to be from a higher income quintile (24.9% v. 15.6%, standardized difference across quintiles 0.31); less likely to reside in an institution (6.3% v. 28.0%, standardized difference 0.6); more likely to be married (48.5% v. 40.6%) and less likely to be widowed (25.7% v. 35.8%, standardized difference 0.34); and more likely to have a cancer diagnosis (64.4% v. 27.6%, standardized difference 0.88 for diagnoses comparisons).

INTERPRETATION

Recipients of MAiD were younger, had higher income, were substantially less likely to reside in an institution and were more likely to be married than decedents from the general population, suggesting that MAiD is unlikely to be driven by social or economic vulnerability. Given the high prevalence of physical and psychologic suffering, despite involvement of palliative care providers in caring for patients who request MAiD, future studies should aim to improve our understanding and treatment of the specific types of suffering that lead to a MAiD request.

摘要

背景

2016 年 6 月,加拿大将医疗协助死亡(MAiD)合法化。有人担心,患者对 MAiD 的请求可能是由于姑息治疗机会不足引起的,而患者的社会和经济脆弱性可能会影响他们获得或接受 MAiD 的机会。为了研究这些问题,我们描述了安大略省在 MAiD 方面的早期经验,并将 MAiD 死亡者与安大略省一般死亡者进行了比较。

方法

我们进行了一项回顾性队列研究,比较了 2016 年 6 月 7 日至 2018 年 10 月 31 日期间,所有与 MAiD 相关的死亡者与安大略省所有死亡者。尽可能为所有 MAiD 死亡者和所有安大略省死亡者收集临床和人口统计学特征。我们使用逻辑回归分析描述了人口统计学和临床因素与接受 MAiD 的关联。

结果

共有 2241 名患者(50.2%为女性)被纳入 MAiD 队列,186814 名患者被纳入安大略省一般死亡者队列。在接受 MAiD 前,接受 MAiD 的患者报告了身体(99.5%)和心理(96.4%)痛苦。在 74.4%的情况下,姑息治疗提供者在 MAiD 请求时参与了患者的护理。有 26.6%的人缩短了法定的 10 天反思期。与所有安大略省死亡者相比,MAiD 接受者年龄较小(平均 74.4 岁与 77.0 岁,标准化差异为 0.18);更有可能来自收入较高的五分位(24.9%与 15.6%,五分位间标准化差异为 0.31);更少居住在机构中(6.3%与 28.0%,标准化差异为 0.6);更有可能已婚(48.5%与 40.6%),而丧偶的可能性较小(25.7%与 35.8%,标准化差异为 0.34);更有可能被诊断患有癌症(64.4%与 27.6%,诊断比较的标准化差异为 0.88)。

解释

与一般人群中的死亡者相比,MAiD 接受者年龄较小,收入较高,居住在机构中的可能性较小,已婚的可能性较大,这表明 MAiD 不太可能是由社会或经济脆弱性驱动的。考虑到身体和心理痛苦的高患病率,尽管姑息治疗提供者参与了照顾请求 MAiD 的患者,但未来的研究应旨在提高我们对导致 MAiD 请求的特定类型痛苦的理解和治疗。

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