小鼠乳头瘤病毒 1：乳头瘤病毒发病机制动物模型的新领域。
Mus musculus Papillomavirus 1: a New Frontier in Animal Models of Papillomavirus Pathogenesis.
机构信息
McArdle Laboratory for Cancer Research, Department of Oncology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA
McArdle Laboratory for Cancer Research, Department of Oncology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA.
出版信息
J Virol. 2020 Apr 16;94(9). doi: 10.1128/JVI.00002-20.
Abstract
Animal models of viral pathogenesis are essential tools in human disease research. Human papillomaviruses (HPVs) are a significant public health issue due to their widespread sexual transmission and oncogenic potential. Infection-based models of papillomavirus pathogenesis have been complicated by their strict species and tissue specificity. In this Gem, we discuss the discovery of a murine papillomavirus, Mus musculus papillomavirus 1 (MmuPV1), and how its experimental use represents a major advancement in models of papillomavirus-induced pathogenesis/carcinogenesis, and their transmission.
摘要
病毒发病机制的动物模型是人类疾病研究的重要工具。人乳头瘤病毒（HPV）因其广泛的性传播和致癌潜能而成为一个重大的公共卫生问题。基于感染的乳头瘤病毒发病机制模型因严格的物种和组织特异性而变得复杂。在这篇综述中，我们讨论了一种小鼠乳头瘤病毒——Mus musculus 乳头瘤病毒 1（MmuPV1）的发现，以及它的实验应用如何代表了在乳头瘤病毒诱导的发病机制/致癌发生及其传播的模型方面的重大进展。
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