Division of Infection and Immunity, Cardiff University School of Medicine, Cardiff University, Cardiff, UK.
Section of Endocrinology, Yale School of Medicine, New Haven, CT, USA.
Nat Rev Endocrinol. 2020 Apr;16(4):198-199. doi: 10.1038/s41574-020-0330-3.
In a cross-sectional study of individuals with type 1 diabetes mellitus, those who were designated to be slow disease progressors had an increased proportion of autoreactive, islet-specific CD8 T cells expressing an ‘exhausted’ phenotype. By contrast, rapid disease progressors had increased numbers of islet-specific CD8 T cells with a transitional memory phenotype.
在一项对 1 型糖尿病患者的横断面研究中，被指定为疾病进展缓慢的患者，其表达“耗竭”表型的自身反应性、胰岛特异性 CD8 T 细胞比例增加。相比之下，疾病快速进展者具有更多的胰岛特异性 CD8 T 细胞，表现出过渡记忆表型。
