预测 T1DM 进展的 CD8 T 细胞表型。
A predictive CD8 T cell phenotype for T1DM progression.
机构信息
Division of Infection and Immunity, Cardiff University School of Medicine, Cardiff University, Cardiff, UK.
Section of Endocrinology, Yale School of Medicine, New Haven, CT, USA.
出版信息
Nat Rev Endocrinol. 2020 Apr;16(4):198-199. doi: 10.1038/s41574-020-0330-3.
Abstract
In a cross-sectional study of individuals with type 1 diabetes mellitus, those who were designated to be slow disease progressors had an increased proportion of autoreactive, islet-specific CD8 T cells expressing an ‘exhausted’ phenotype. By contrast, rapid disease progressors had increased numbers of islet-specific CD8 T cells with a transitional memory phenotype.
摘要
在一项对 1 型糖尿病患者的横断面研究中，被指定为疾病进展缓慢的患者，其表达“耗竭”表型的自身反应性、胰岛特异性 CD8 T 细胞比例增加。相比之下，疾病快速进展者具有更多的胰岛特异性 CD8 T 细胞，表现出过渡记忆表型。
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