Laboratory of Biorheology and Medical Ultrasonics, University of Montreal Hospital Research Center (CRCHUM), Montréal, QC, H2X 0A9, Canada.
Department of Internal Medicine, University of Montreal Hospital Center (CHUM), Montréal, QC, H2X 0C1, Canada.
Eur Radiol. 2020 Jun;30(6):3178-3187. doi: 10.1007/s00330-020-06660-9. Epub 2020 Feb 12.
Assess carotid artery strain and motion in people living with HIV as markers of premature aging using ultrasound noninvasive vascular elastography (NIVE).
Seventy-four HIV-infected and 75 age-matched control subjects were recruited from a prospective, controlled cohort study from October 2015 to October 2017 (mean age 56 years ± 8 years; 128 men). NIVE applied to longitudinal ultrasound images of common and internal carotid arteries quantified the cumulated axial strain, cumulated shear strain, cumulated axial translation, and cumulated lateral translations. The presence of plaque was also assessed. An association between elastography biomarkers and HIV status was evaluated with Mann-Whitney tests and multivariable linear regression models.
A higher occurrence of carotid artery plaques was found in HIV-infected individuals (p = 0.011). Lower cumulated lateral translations were found in HIV-infected subjects on both common and internal carotid arteries (p = 0.037 and p = 0.026, respectively). These observations remained significant when considering multivariable models including common cardiovascular risk factors and clinical characteristics (p < 0.05). Lower cumulated axial strains were also observed in internal carotid arteries when considering both multivariable models (p < 0.05).
Lower translation and strain of the carotid artery wall in HIV-infected individuals indicates increased vessel wall stiffness. These new imaging biomarkers could be used to characterize premature atherosclerosis development.
• Noninvasive vascular elastography (NIVE) based on ultrasound imaging quantifies translations and strains of carotid arteries. • Lower translation and strain of the carotid artery wall found in HIV-infected individuals indicate premature arterial stiffening, compared with age-matched controls. • Carotid artery plaques were more prevalent in HIV-infected individuals than in control subjects.
使用超声无创血管弹性成像（NIVE）评估艾滋病毒感染者颈动脉应变和运动，作为早衰的标志物。
2015 年 10 月至 2017 年 10 月，从一项前瞻性对照队列研究中招募了 74 名艾滋病毒感染者和 75 名年龄匹配的对照组受试者（平均年龄 56 岁±8 岁；128 名男性）。NIVE 应用于颈总动脉和颈内动脉的纵向超声图像，量化了累积轴向应变、累积剪切应变、累积轴向位移和累积侧向位移。还评估了斑块的存在。采用 Mann-Whitney 检验和多变量线性回归模型评估弹性成像生物标志物与 HIV 状态的相关性。
HIV 感染者颈动脉斑块的发生率较高（p=0.011）。HIV 感染者颈总动脉和颈内动脉的累积侧向位移较低（p=0.037 和 p=0.026）。当考虑包括常见心血管危险因素和临床特征的多变量模型时，这些观察结果仍然具有统计学意义（p<0.05）。当考虑两种多变量模型时，颈内动脉的累积轴向应变也较低（p<0.05）。
HIV 感染者颈动脉壁的低位移和应变表明血管壁僵硬增加。这些新的影像学生物标志物可用于描述动脉粥样硬化的早期发展。
基于超声成像的无创血管弹性成像（NIVE）量化了颈动脉的位移和应变。
HIV 感染者的颈动脉壁位移和应变降低，表明与年龄匹配的对照组相比，动脉早期僵硬。
与对照组相比，HIV 感染者颈动脉斑块更为常见。
