Department of Medical Microbiology and Immunology, School of Medicine, University of California, Davis, CA, 95616, USA.
Division of Infectious Disease, Department of Medicine, School of Medicine, University of California, Davis, CA, 95616, USA.
Curr HIV/AIDS Rep. 2020 Apr;17(2):109-117. doi: 10.1007/s11904-020-00481-7.
This review summarizes recent literature defining tissue-resident memory T cells (T) and discusses implications for HIV pathogenesis, vaccines, and eradication efforts.
Investigations using animal models and human tissues have identified a T transcriptional profile and elucidated signals within the tissue microenvironment leading to T development and maintenance. T are major contributors to host response in infectious diseases and cancer; in addition, T contribute to pathogenic inflammation in a variety of settings. Although T are daunting to study in HIV infection, recent work has helped define their molecular signatures and effector functions and tested strategies for their mobilization. Exclusive reliance on blood sampling to gain an understanding of host immunity overlooks the contribution of T, which differ in significant ways from their counterparts in circulation. It is hoped that greater understanding of these cells will lead to novel approaches to prevent and/or eradicate HIV infection.
本文总结了最近关于组织驻留记忆 T 细胞（T）的文献，讨论了其对 HIV 发病机制、疫苗和清除工作的影响。
利用动物模型和人体组织进行的研究确定了 T 的转录特征，并阐明了组织微环境内导致 T 发育和维持的信号。T 是宿主对传染病和癌症反应的主要贡献者；此外，T 在多种情况下也导致致病性炎症。尽管在 HIV 感染中研究 T 细胞极具挑战性，但最近的工作有助于定义其分子特征和效应功能，并测试了动员它们的策略。仅仅依靠血液采样来了解宿主免疫会忽略 T 的贡献，T 在许多方面与循环中的 T 细胞不同。人们希望对这些细胞有更深入的了解，从而为预防和/或清除 HIV 感染带来新的方法。
