Department of Physical Sciences, Peter MacCallum Cancer Centre, Melbourne, Vic, Australia.
Centre for Medical Radiation Physics, University of Wollongong, Wollongong, NSW, Australia.
J Appl Clin Med Phys. 2020 Mar;21(3):62-67. doi: 10.1002/acm2.12825. Epub 2020 Feb 13.
Four-dimensional computerized tomography (4DCT) is required for stereotactic ablative body radiotherapy (SABR) of mobile targets to account for tumor motion during treatment planning and delivery. In this study, we report on the impact of an image review quality assurance process performed prior to treatment planning by medical physicists for 4DCT scans used for SABR treatment. Reviews were performed of 211 4DCT scans (193 patients) over a 3-yr period (October 2014 to October 2017). Treatment sites included lung (n = 168), kidney/adrenal/adrenal gland (n = 12), rib (n = 4), mediastinum (n = 10), liver (n = 2), T-spine (n = 1), and other abdominal sites (n = 14). It was found that in 23% (n = 49) of cases patient management was altered due to the review process. The most frequent intervention involved patient-specific contouring advice (n = 35 cases, 17%) including adjustment of internal target volume (ITV) margins. In 13 cases (6%) a rescan was requested due to extensive motion artifact rendering the scan inadequate for SABR treatment planning. 4DCT review by medical physicists was found to be an effective method to improve plan quality for SABR.
四维计算机断层扫描(4DCT)对于移动目标的立体定向消融体放射治疗(SABR)是必需的,以在治疗计划和交付过程中考虑肿瘤运动。在这项研究中,我们报告了在治疗计划之前由医学物理学家对用于 SABR 治疗的 4DCT 扫描进行图像审查质量保证过程对治疗的影响。在 3 年的时间内(2014 年 10 月至 2017 年 10 月),对 211 个 4DCT 扫描(193 名患者)进行了回顾。治疗部位包括肺(n=168)、肾/肾上腺/肾上腺(n=12)、肋骨(n=4)、纵隔(n=10)、肝(n=2)、T 脊柱(n=1)和其他腹部部位(n=14)。结果发现,由于审查过程,23%(n=49)的患者管理发生了变化。最常见的干预措施包括特定于患者的轮廓建议(n=35 例,17%),包括调整内部靶区(ITV)边界。由于运动伪影广泛,13 例(6%)需要重新扫描,导致扫描不适合 SABR 治疗计划。医学物理学家对 4DCT 的审查被发现是一种提高 SABR 计划质量的有效方法。