Aljaafari Lamyaa, Bird David, Buckley David L, Al-Qaisieh Bashar, Speight Richard
Leeds Institute of Cardiovascular & Metabolic Medicine (LICAMM), University of Leeds, Woodhouse, Leeds, LS2 9JT, United Kingdom.
Department of Medical Physics and Engineering, Leeds Teaching Hospitals NHS Trust, Leeds, LS9 7TF, United Kingdom.
Phys Imaging Radiat Oncol. 2024 Jul 4;31:100604. doi: 10.1016/j.phro.2024.100604. eCollection 2024 Jul.
Four-dimensional magnetic resonance imaging (4DMRI) has gained interest as an alternative to the current standard for motion management four-dimensional tomography (4DCT) in abdominal radiotherapy treatment planning (RTP). This review aims to assess the 4DMRI literature in abdomen, focusing on technical considerations and the validity of using 4DMRI for patients within radiotherapy protocols.
The review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. A comprehensive search was performed across the Medline, Embase, Scopus, and Web of Science databases, covering all years up to December 31, 2023. The studies were grouped into two categories: 4DMRI reconstructed from 3DMRI acquisition; and 4DMRI reconstructed from multi-slice 2DMRI acquisition.
A total of 39 studies met the inclusion criteria and were analysed to provide key findings. Key findings were 4DMRI had the potential to improve abdominal RTP for patients by providing accurate tumour definition and motion assessment compared to 4DCT. 4DMRI reconstructed from 3DMRI acquisition showed promise as a feasible approach for motion management in abdominal RTP regarding spatial resolution. Currently,the slice thickness achieved on 4DMRI reconstructed from multi-slice 2DMRI acquisitions was unsuitable for clinical purposes. Lastly, the current barriers for clinical implementation of 4DMRI were the limited availability of validated commercial solutions and the lack of larger cohort comparative studies to 4DCT for target delineation and plan optimisation.
4DMRI showed potential improvements in abdominal RTP, but standards and guidelines for the use of 4DMRI in radiotherapy were required to demonstrate clinical benefits.
在腹部放射治疗计划（RTP）中，四维磁共振成像（4DMRI）作为当前运动管理标准方法四维断层扫描（4DCT）的替代方法，已引起关注。本综述旨在评估腹部4DMRI的相关文献，重点关注技术考量以及在放射治疗方案中对患者使用4DMRI的有效性。
本综述遵循系统评价和Meta分析的首选报告项目（PRISMA）指南。对Medline、Embase、Scopus和科学网数据库进行了全面检索，涵盖截至2023年12月31日的所有年份。这些研究分为两类：从3DMRI采集重建的4DMRI；以及从多层2DMRI采集重建的4DMRI。
共有39项研究符合纳入标准并进行了分析以提供关键发现。关键发现包括与4DCT相比，4DMRI有潜力通过提供准确的肿瘤定义和运动评估来改善腹部RTP。从3DMRI采集重建的4DMRI在腹部RTP的运动管理方面，就空间分辨率而言显示出作为一种可行方法的前景。目前，从多层2DMRI采集重建的4DMRI所实现的切片厚度不适合临床应用。最后，4DMRI临床应用的当前障碍是经过验证的商业解决方案可用性有限，以及缺乏针对4DCT的更大队列比较研究以进行靶区勾画和计划优化。
4DMRI在腹部RTP中显示出潜在的改善，但需要4DMRI在放射治疗中使用的标准和指南来证明其临床益处。
