Nutrition and Health Research Centre, By-Health Co. Ltd, No. 3 Kehui 3rd Street, No. 99 Kexue Avenue Central, Science City, Huangpu District, Guangzhou, 510633, China.
Department of Nutrition and Food Hygiene, School of Public Health, Southern Medical University, Guangzhou North Avenue 1838, Guangzhou, 510515, People's Republic of China.
BMC Public Health. 2020 Feb 13;20(1):226. doi: 10.1186/s12889-020-8323-7.
Evidence suggests that body composition has impact on arterial stiffness. However, evidence in Chinese are limited, and results remain controversial. The aim of our study is to investigate whether skeletal muscle mass is associated with arterial stiffness in Chinese community-dwelling men and women aged 45 years and older.
In this cross-sectional study, 20,477 participants (age range: 45-80 years, 68.8% women) were included in the analysis. Brachial-ankle pulse wave velocity (baPWV), an indicator of arterial stiffness was measured using a waveform device. Total muscle mass and muscle mass of arm, leg and trunk were measured by bioelectrical impedance analysis. Height and weight were measured and appendicular skeletal muscle mass index (ASMI) was calculated as appendicular skeletal muscle mass (sum of arm and leg muscle mass) divided by height square.
After adjustment for age, body fat percentage, systolic blood pressure and diastolic blood pressure, ASMI was negatively associated with baPWV [β (SE) for men: - 0.208 (0.016), p < 0.0001; for women: - 0.245 (0.012), p < 0.0001]. High ASMI was a protective factor for the presence of arterial stiffness (defined as baPWV) [OR (95%CI) for men: 0.730 (0.682, 0.782), p < 0.0001; women: 0.634 (0.593, 0.677), p < 0.0001]. Similar associations were found between quantity of muscle mass (total and appendicular muscle mass, muscle mass of arm, leg and trunk) and arterial stiffness in men and women after further adjustment for height (all p < 0.0001).
Low skeletal muscle mass is associated with increased risk of arterial stiffness in Chinese community-dwelling adults aged 45 years and older.
有证据表明，人体成分会对动脉僵硬度产生影响。然而，中国的相关证据有限，结果仍存在争议。我们的研究目的是调查在中国社区居住的 45 岁及以上的男性和女性中，骨骼肌量是否与动脉僵硬度有关。
在这项横断面研究中，共纳入 20477 名参与者（年龄范围：45-80 岁，68.8%为女性）进行分析。使用波形装置测量肱踝脉搏波速度（baPWV），这是动脉僵硬度的一个指标。通过生物电阻抗分析测量总肌肉量以及手臂、腿部和躯干的肌肉量。测量身高和体重，并计算四肢骨骼肌指数（ASMI），即四肢骨骼肌量（手臂和腿部肌肉量之和）除以身高的平方。
在校正年龄、体脂百分比、收缩压和舒张压后，ASMI 与 baPWV 呈负相关[男性：-0.208（0.016），p<0.0001；女性：-0.245（0.012），p<0.0001]。高 ASMI 是动脉僵硬度（定义为 baPWV）存在的保护因素[男性：OR（95%CI）为 0.730（0.682，0.782），p<0.0001；女性：0.634（0.593，0.677），p<0.0001]。在校正身高后，男性和女性的总肌肉量和四肢肌肉量以及手臂、腿部和躯干的肌肉量与动脉僵硬度之间也存在类似的关联（均 p<0.0001）。
在中国社区居住的 45 岁及以上成年人中，骨骼肌量低与动脉僵硬度增加的风险相关。
