社区居住老年人中骨骼肌减少症不同成分与肱踝脉搏波速度的横断面研究。
A cross-sectional study of the relationships between different components of sarcopenia and brachial ankle pulse wave velocity in community-dwelling elderly.
机构信息
Health Management Centre, Tianjin First Central Hospital, No. 24 of Fukang Road, Nankai District, Tianjin, 300192, China.
Department of Geratology, Tianjin First Central Hospital, No. 24 of Fukang Road, Nankai District, Tianjin, 300192, China.
出版信息
BMC Geriatr. 2020 Mar 30;20(1):115. doi: 10.1186/s12877-020-01525-8.
BACKGROUND
Previous studies have just found skeletal muscle mass decline is associated with arterial stiffness, but it is unclear whether muscle strength and physical performance as important compositions of sarcopenia are associated with arterial stiffness. The aim of this study was to investigate the relationship between sarcopenia, the components of sarcopenia and arterial stiffness among elderly in the community.
METHODS
This study enrolled 450 elderly people who received general medical examinations in Tianjin First Center Hospital. Each of the subjects was greater than 65 years old, including 266 male and 184 female subjects. Based on the diagnostic criteria for sarcopenia in older people developed by the Asian Working Group for Sarcopenia (AWGS), 89 subjects were separated into the sarcopenia group. The living habits, disease status, general status and laboratory examinations of all subjects were collected. The body composition (including appendicular skeletal muscle mass and visceral fat area (VFA) of each participant) was measured by bioimpedance analysis. HS, usual gait speed (GS), and brachial ankle pulse wave velocity (baPWV) were measured.
RESULTS
Sarcopenia subjects had higher baPWV, nutrition risk and lower appendicular skeletal muscle index (ASMI), Handgrip strength (HS), GS, body mass index (BMI), triacylglycerol (TG), serum albumin (ALB) and creatinine (Cr) than did non-sarcopenia subjects; Sarcopenia subjects also had higher visceral fat area (VFA) than did non-sarcopenia subjects (p < 0.05). ASMI and HS were negatively associated with baPWV (t = - 5.807, p = 0.000 and t = - 3.085, p = 0.002), but the relationship between baPWV and GS was not statistically significant (t = - 0.862, p = 0.389) by multivariable linear regression. After adjusting for confounders, a multivariate logistic regression analysis revealed that sarcopenia was related with age, BMI, sports and baPWV in community dwelling elderly.
CONCLUSIONS
ASMI and HS were negatively associated with baPWV in community dwelling elderly in China; and baPWV was a risk factor of sarcopenia.
背景
先前的研究仅发现骨骼肌质量下降与动脉僵硬有关，但尚不清楚肌强度和身体表现作为肌少症的重要组成部分是否与动脉僵硬有关。本研究旨在探讨社区老年人中肌少症、肌少症的组成部分与动脉僵硬之间的关系。
方法
本研究纳入了在天津市第一中心医院接受常规体检的 450 名老年人。所有受试者年龄均大于 65 岁，包括 266 名男性和 184 名女性。根据亚洲肌少症工作组（AWGS）制定的老年人肌少症诊断标准，89 名受试者被分为肌少症组。收集所有受试者的生活习惯、疾病状况、一般状况和实验室检查。通过生物电阻抗分析测量每位参与者的身体成分（包括四肢骨骼肌质量和内脏脂肪面积（VFA））。测量了脉搏波速度（HS）、常规步态速度（GS）和肱踝脉搏波速度（baPWV）。
结果
与非肌少症受试者相比，肌少症受试者的 baPWV、营养风险和较低的四肢骨骼肌指数（ASMI）、握力（HS）、GS、体重指数（BMI）、三酰甘油（TG）、血清白蛋白（ALB）和肌酐（Cr）更高；肌少症受试者的内脏脂肪面积（VFA）也高于非肌少症受试者（p<0.05）。多元线性回归分析显示，ASMI 和 HS 与 baPWV 呈负相关（t=-5.807，p=0.000 和 t=-3.085，p=0.002），但 GS 与 baPWV 之间的关系无统计学意义（t=-0.862，p=0.389）。多元逻辑回归分析显示，在校正混杂因素后，肌少症与年龄、BMI、运动和社区居住老年人的 baPWV 有关。
结论
在中国社区居住的老年人中，ASMI 和 HS 与 baPWV 呈负相关；而 baPWV 是肌少症的危险因素。
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