Biochemistry & Toxicology Division, Department of Zoology, University of Calicut, Kerala, 673 635, India.
Sci Rep. 2020 Feb 13;10(1):2612. doi: 10.1038/s41598-020-59169-y.
Underwater adhesion in mussels (Bivalvia) is an extreme adaptation to achieve robust and firm wet adhesion in the freshwater/brackish/ocean, which biochemically shaped through millions of years. The protein-based adhesion has huge prospective in various fields like industry, medical, etc. Currently, no comprehensive records related to the systematic documentation of structural and functional properties of Mussel foot proteins (Mfps). In this study, we identified the nine species of bivalves in which the complete sequence of at least one adhesive protein is known. The insilico characterization revealed the specific physio-chemical structural and functional characters of each Mfps. The evolutionary analyses of selected bivalves are mainly based on Mfps, Mitogenome, and TimeTree. The outcome of the works has great applications for designing biomimetic materials in future.
贻贝（双壳类）的水下附着是一种极端的适应，使其能够在淡水/半咸水/海洋中实现强大而牢固的湿附着，这一适应是经过数百万年的生物化学进化形成的。基于蛋白质的附着在工业、医学等各个领域都具有巨大的应用前景。目前，还没有关于贻贝足部蛋白（Mfps）的结构和功能特性的系统文献记录。在这项研究中，我们鉴定了 9 种双壳类动物，其中至少有一种粘附蛋白的完整序列是已知的。计算机模拟分析揭示了每个 Mfps 的特定理化结构和功能特征。选定双壳类动物的进化分析主要基于 Mfps、线粒体基因组和 TimeTree。这项工作的结果对于未来设计仿生材料具有重要的应用价值。
