1] School of Materials Science and Engineering, Nanyang Technological University, Singapore. [2].
Nat Biotechnol. 2013 Oct;31(10):908-15. doi: 10.1038/nbt.2671. Epub 2013 Sep 8.
Efforts to engineer new materials inspired by biological structures are hampered by the lack of genomic data from many model organisms studied in biomimetic research. Here we show that biomimetic engineering can be accelerated by integrating high-throughput RNA-seq with proteomics and advanced materials characterization. This approach can be applied to a broad range of systems, as we illustrate by investigating diverse high-performance biological materials involved in embryo protection, adhesion and predation. In one example, we rapidly engineer recombinant squid sucker ring teeth proteins into a range of structural and functional materials, including nanopatterned surfaces and photo-cross-linked films that exceed the mechanical properties of most natural and synthetic polymers. Integrating RNA-seq with proteomics and materials science facilitates the molecular characterization of natural materials and the effective translation of their molecular designs into a wide range of bio-inspired materials.
受仿生研究中许多模式生物基因组数据缺乏的阻碍，受生物结构启发而设计新材料的努力举步维艰。在这里，我们展示了通过将高通量 RNA-seq 与蛋白质组学和先进的材料特性相结合，可以加速仿生工程。正如我们通过研究涉及胚胎保护、粘附和捕食的各种高性能生物材料所说明的那样，这种方法可以应用于广泛的系统。在一个例子中，我们将鱿鱼吸盘环齿蛋白快速工程化为一系列结构和功能材料，包括纳米图案表面和光交联薄膜，其机械性能超过大多数天然和合成聚合物。将 RNA-seq 与蛋白质组学和材料科学相结合，促进了对天然材料的分子表征，并有效地将其分子设计转化为广泛的仿生材料。
