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SAPCD2的过表达与结肠癌细胞的增殖和侵袭相关。

Overexpression of SAPCD2 correlates with proliferation and invasion of colorectal carcinoma cells.

作者信息

Luo Yage, Wang Lili, Ran Wenwen, Li Guangqi, Xiao Yujing, Wang Xiaonan, Zhao Han, Xing Xiaoming

机构信息

1Department of Pathology, The Affiliated Hospital of Qingdao University, 16 Jiangsu Road, Qingdao, 266000 Shandong People's Republic of China.

2Department of Pathology, Qingdao University Basic Medicine College, Qingdao, 266000 Shandong People's Republic of China.

出版信息

Cancer Cell Int. 2020 Feb 6;20:43. doi: 10.1186/s12935-020-1121-6. eCollection 2020.

DOI:10.1186/s12935-020-1121-6
PMID:32055236
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7006392/
Abstract

BACKGROUND

Suppressor anaphase-promoting complex domain containing 2 (SAPCD2) is a novel gene playing important roles in the initiation, invasion, and metastasis of several malignancies. However, its role in colorectal carcinoma (CRC) still remains unclear.

METHOD

In this study, we investigated the expression and biological function of SAPCD2 in CRC. Immunohistochemistry (IHC) for SAPCD2 was performed in 410 pairs of CRC specimens and corresponding normal epithelial tissues, and in 50 adenoma tissues. Clinical pathological factors were analyzed in relation to the expression of SAPCD2. The biological functions of SAPCD2 in CRC cells and its effect on cell cycle were investigated in vitro and in vivo through gain/loss-of-function approaches.

RESULTS

IHC showed that SAPCD2 expression was significantly higher in CRC tissues compared to adenoma and normal epithelium tissues and was correlated with tumor location (= 0.018). SAPCD2 significantly promoted cell proliferation, migration, and invasion both in vitro and in vivo (< 0.05). In addition, SAPCD2 knockdown in CRC cells was associated with reduced G/S transition, while overexpression caused G/M phase arrest (< 0.05).

CONCLUSIONS

In sum, SAPCD2 is overexpressed in CRC tissues and plays a critical role in CRC progression. Therefore, it might represent a promising therapeutic target for CRC treatment.

摘要

背景

含抑制后期促进复合体结构域2（SAPCD2）是一种新基因，在多种恶性肿瘤的发生、侵袭和转移中起重要作用。然而，其在结直肠癌（CRC）中的作用仍不清楚。

方法

在本研究中，我们调查了SAPCD2在CRC中的表达及生物学功能。对410对CRC标本及相应的正常上皮组织，以及50例腺瘤组织进行了SAPCD2的免疫组织化学（IHC）检测。分析了临床病理因素与SAPCD2表达的关系。通过功能获得/丧失方法在体外和体内研究了SAPCD2在CRC细胞中的生物学功能及其对细胞周期的影响。

结果

IHC显示，与腺瘤和正常上皮组织相比，CRC组织中SAPCD2表达显著更高，且与肿瘤位置相关（= 0.018）。SAPCD2在体外和体内均显著促进细胞增殖、迁移和侵袭（< 0.05）。此外，CRC细胞中SAPCD2敲低与G/S期转换减少相关，而过表达导致G/M期阻滞（< 0.05）。

结论

总之，SAPCD2在CRC组织中过表达，在CRC进展中起关键作用。因此，它可能是CRC治疗的一个有前景的治疗靶点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c83d/7006392/f89283e29166/12935_2020_1121_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c83d/7006392/278bde5bbcd6/12935_2020_1121_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c83d/7006392/d13ba42ffcd9/12935_2020_1121_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c83d/7006392/2b3ed1fbb2f5/12935_2020_1121_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c83d/7006392/1ba67a79fe77/12935_2020_1121_Fig4a_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c83d/7006392/8bbd4961714c/12935_2020_1121_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c83d/7006392/f89283e29166/12935_2020_1121_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c83d/7006392/278bde5bbcd6/12935_2020_1121_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c83d/7006392/d13ba42ffcd9/12935_2020_1121_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c83d/7006392/2b3ed1fbb2f5/12935_2020_1121_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c83d/7006392/1ba67a79fe77/12935_2020_1121_Fig4a_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c83d/7006392/8bbd4961714c/12935_2020_1121_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c83d/7006392/f89283e29166/12935_2020_1121_Fig6_HTML.jpg

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