Shayganfar Azin, Ebrahimian Shadi, Masjedi Mahsa, Daryaei Sadaf
Department of Radiology, Isfahan University of Medical Sciences, Isfahan, Iran.
J Res Med Sci. 2020 Jan 20;25:4. doi: 10.4103/jrms.JRMS_1066_18. eCollection 2020.
Osteoporosis is known as reduction of bone density, which is diagnosed using dual-energy X-ray absorptiometry. Although some studies have shown high body mass index (BMI) as a protective factor for osteoporosis and fracture risks, some other studies demonstrated obesity as a risk factor for osteoporosis. The aim of this study is to evaluate the relationship between BMI and bone mineral density (BMD) in premenopausal and postmenopausal females. Furthermore, we determined the correlation between BMI and fracture risk in postmenopausal females.
In this study, we evaluated the relationship between the age and BMI with 10-year probability fracture risk (estimated using fracture risk assessment tool) and BMD in the L1-L4 spine and femoral neck. Data were collected from BMD center, Askariye Hospital, Isfahan, Iran, from May 2016 to July 2017.
The study consisted of 1361 individuals, including 305 premenopausal females and 1056 postmenopausal females. The results showed a statistically significant increase of BMD ( < 0.001) and a decrease of fracture risk ( = -0.158, = 0.518) with an increase of BMI in postmenopausal females. Moreover, lumbar spine and femoral neck BMD were significantly higher in individuals with BMI ≥30 than in those with BMI <25 in both premenopausal and postmenopausal females ( < 0.001). In addition, older postmenopausal females indicated significantly lower L1-L4 BMD ( = -0.280, < 0.05) and femoral neck BMD ( = -0.358, < 0.05).
The results showed a positive correlation between BMI and BMD of the spine and femoral neck which did not differ by menopausal status. However, there was a correlation between BMI and fracture risk in postmenopausal females.
骨质疏松症表现为骨密度降低，通过双能X线吸收法进行诊断。尽管一些研究表明高体重指数（BMI）是骨质疏松症和骨折风险的保护因素，但其他一些研究则表明肥胖是骨质疏松症的风险因素。本研究的目的是评估绝经前和绝经后女性中BMI与骨矿物质密度（BMD）之间的关系。此外，我们还确定了绝经后女性中BMI与骨折风险之间的相关性。
在本研究中，我们评估了年龄和BMI与10年骨折概率风险（使用骨折风险评估工具估算）以及L1-L4脊柱和股骨颈骨密度之间的关系。数据于2016年5月至2017年7月从伊朗伊斯法罕阿斯卡里耶医院的骨密度中心收集。
该研究共纳入1361名个体，其中包括305名绝经前女性和1056名绝经后女性。结果显示，绝经后女性的BMI升高时，骨密度有统计学意义的显著增加（<0.001），骨折风险降低（=-0.158，=0.518）。此外，绝经前和绝经后女性中，BMI≥30的个体的腰椎和股骨颈骨密度均显著高于BMI<25的个体（<0.001）。另外，绝经后年龄较大的女性的L1-L4骨密度（=-0.280，<0.05）和股骨颈骨密度（=-0.358，<0.05）显著较低。
结果表明，BMI与脊柱和股骨颈的骨密度呈正相关，且不受绝经状态影响。然而，绝经后女性的BMI与骨折风险之间存在相关性。
