Xu Gaoran, Chen Junzhu, Wang Guorong, Xiao Junhong, Zhang Ning, Chen Yanyu, Yu Haoran, Wang Guangzhi, Zhao Yongfu
Department of General Surgery, The Second Hospital of Dalian Medical University, Dalian 116000, China.
Mol Ther Oncolytics. 2020 Jan 10;16:124-133. doi: 10.1016/j.omto.2019.12.010. eCollection 2020 Mar 27.
Follicular thyroid carcinoma (FTC) is a common endocrine malignancy with highly aggressive features. In this study, next-generation sequencing technology was used to identify aberrant expression of sialyltransferase (ST) family members in FTC. Aberrant high expression of alpha-2,6-sialyltransferase 2 (ST6GAL2) was demonstrated to promote tumorigenesis of FTC and . Furthermore, ST6GAL2 promoted tumorigenesis by inactivating the Hippo signaling pathway. Resveratrol is a native compound extracted from species, and many studies have confirmed its protective cardiovascular and antineoplastic effects. Here we found that resveratrol can inhibit the tumorigenesis of FTC by suppressing the expression of ST6GAL2, further activating the Hippo pathway. In summary, this study revealed the role of the ST6GAL2-Hippo signaling pathway in FTC tumorigenesis and indicated that resveratrol, a commonly found antineoplastic compound, could inhibit tumorigenesis of FTC by regulating the abovementioned pathways.
滤泡性甲状腺癌（FTC）是一种具有高度侵袭性特征的常见内分泌恶性肿瘤。在本研究中，采用新一代测序技术来鉴定FTC中唾液酸转移酶（ST）家族成员的异常表达。已证实α-2,6-唾液酸转移酶2（ST6GAL2）的异常高表达促进FTC的肿瘤发生。此外，ST6GAL2通过使Hippo信号通路失活来促进肿瘤发生。白藜芦醇是从 物种中提取的天然化合物，许多研究已证实其具有保护心血管和抗肿瘤作用。在此我们发现，白藜芦醇可通过抑制ST6GAL2的表达来抑制FTC的肿瘤发生，进而激活Hippo通路。总之，本研究揭示了ST6GAL2-Hippo信号通路在FTC肿瘤发生中的作用，并表明白藜芦醇这种常见的抗肿瘤化合物可通过调节上述通路来抑制FTC的肿瘤发生。
