UCLA Department of Psychiatry, Semel Institute for Neuroscience and Human Behavior, Los Angeles, California.
Pacific Neuroscience Institute, Santa Monica, California.
Early Interv Psychiatry. 2021 Feb;15(1):213-216. doi: 10.1111/eip.12946. Epub 2020 Feb 13.
Elevated levels of pro-inflammatory cytokines have been reported in meta-analyses of multi-episode schizophrenia patients when compared to controls. However, little is known about whether these same relationships are present in the early course of schizophrenia.
To assess first episode schizophrenia patients for depression and to assay blood samples collected at baseline and at 6 months for interleukin-6 (IL-6).
Trained raters used the Brief Psychiatric Rating Scale to assess depressive symptoms and a standard lab assay kit to assess for IL-6 levels in plasma.
Decreases in pro-inflammatory IL-6 levels were significantly related to decreases in depressive symptoms. Within a subset of patients in a 6-month aerobic exercise protocol, the number of exercise sessions completed was significantly correlated with the amount of decrease in IL-6. The reductions observed in IL-6 with aerobic exercise suggest exercise is a promising intervention to reduce brain inflammation effects in schizophrenia patients.
与对照组相比，多项发作性精神分裂症患者的分析报告显示，促炎细胞因子水平升高。然而，目前尚不清楚这些相同的关系是否存在于精神分裂症的早期阶段。
评估首发精神分裂症患者的抑郁情况，并检测基线和 6 个月时采集的血液样本中的白细胞介素-6 (IL-6)。
经过培训的评估员使用简明精神病评定量表评估抑郁症状，使用标准实验室试剂盒评估血浆中的 IL-6 水平。
促炎细胞因子 IL-6 水平的降低与抑郁症状的降低显著相关。在一项为期 6 个月的有氧运动方案的患者亚组中，完成的运动次数与 IL-6 降低的幅度呈显著相关。有氧运动中观察到的 IL-6 减少表明，运动是一种很有前途的干预措施，可以减少精神分裂症患者大脑炎症的影响。
