Zhang Youcan, Yin Zhiping, Wu Xiao-Feng
Leibniz-Institut für Katalyse e.V. an der Universität Rostock, Albert-Einstein-Straße 29a, 18059 Rostock, Germany.
Org Lett. 2020 Mar 6;22(5):1889-1893. doi: 10.1021/acs.orglett.0c00227. Epub 2020 Feb 14.
A new methodology for the carbonylative transformation of -fluoro-sulfonamides into -sulfonyl-β-homoproline esters has been described. In the presence of a catalytic amount of Cu(OTf), a range of β-homoproline derivatives were prepared in moderate to good yield. The reaction proceeds via the intramolecular cyclization and intermolecular carbonylation of a free carbon radical. Notably, this procedure offers the possibility to build potential functionalized bioactive molecules.
已描述了一种将β-氟磺酰胺羰基化转化为β-磺酰基-β-高脯氨酸酯的新方法。在催化量的三氟甲磺酸铜（Cu(OTf)）存在下，制备了一系列产率中等至良好的β-高脯氨酸衍生物。该反应通过自由基的分子内环化和分子间羰基化进行。值得注意的是，该方法为构建潜在的功能化生物活性分子提供了可能性。
