铁催化的γ,δ-不饱和芳香肟酯与胺的羰基化环化反应
Iron-catalyzed carbonylative cyclization of γ,δ-unsaturated aromatic oxime esters with amines.
作者信息
Zhang Youcan, Wu Xiao-Feng
机构信息
Leibniz-Institut für Katalyse e. V. an der Universität Rostock, Albert-Einstein-Straße 29a, Rostock 18059, Germany.
出版信息
Chem Commun (Camb). 2020 Dec 4;56(93):14605-14608. doi: 10.1039/d0cc06671k. Epub 2020 Nov 5.
An efficient iron-catalyzed carbonylative cyclization of γ,δ-unsaturated aromatic oxime esters with amines has been developed. A range of functionalized β-homoproline amide derivatives were prepared via an iminyl radical-mediated intramolecular 1,5-cyclization followed by carbon radical-triggered intermolecular carbonylation. Examples on further transforming the obtained product were successfully discussed as well.
已开发出一种高效的铁催化γ,δ-不饱和芳族肟酯与胺的羰基化环化反应。通过亚胺基自由基介导的分子内1,5-环化，随后碳自由基引发的分子间羰基化反应，制备了一系列功能化的β-高脯氨酸酰胺衍生物。还成功讨论了进一步转化所得产物的实例。
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