Alamzeb Muhammad, Omer Muhammad, Abid Obaid-Ur-Rahman, Ullah Mohib, Sohail Muhammad, Ullah Ihsan
Institute of Chemical Sciences, University of Swat, Swat, Pakistan.
Department of Chemistry, University of Kotli, Kotli, Pakistan.
Front Chem. 2023 Jul 26;11:1185669. doi: 10.3389/fchem.2023.1185669. eCollection 2023.
Drug design and delivery is primarily based on the hunt for new potent drug candidates and novel synthetic techniques. Recently, saturated heterocycles have gained enormous attention in medicinal chemistry as evidenced by the medicinal drugs listed in the FDA Orange Book. Therefore, the demand for novel saturated heterocyclic syntheses has increased tremendously. Transition metal (TM)-catalyzed reactions have remained the prime priority in heterocyclic syntheses for the last three decades. Nowadays, TM catalysis is well adorned by combining it with other techniques such as bio- and/or enzyme-catalyzed reactions, organocatalysis, or using two different metals in a single catalysis. This review highlights the recent developments of the transition metal-catalyzed synthesis of five-membered saturated heterocycles.
药物设计与递送主要基于寻找新的高效候选药物和新颖的合成技术。近来，饱和杂环在药物化学领域受到了极大关注，美国食品药品监督管理局（FDA）橙皮书中列出的药物便是明证。因此，对新型饱和杂环合成方法的需求急剧增加。在过去三十年里，过渡金属（TM）催化反应一直是杂环合成中的首要重点。如今，通过将TM催化与其他技术相结合，如生物和/或酶催化反应、有机催化，或在单一催化中使用两种不同金属，TM催化得到了进一步完善。本综述重点介绍了过渡金属催化合成五元饱和杂环的最新进展。
