Department of Clinical Laboratory, Renmin Hospital of Wuhan University, Wuhan 430060, China.
Department of Clinical Laboratory, Renmin Hospital of Wuhan University, Wuhan 430060, China.
J Affect Disord. 2020 Mar 1;264:256-262. doi: 10.1016/j.jad.2020.01.010. Epub 2020 Jan 7.
This prospective investigation examined relations between dietary trans fatty acid intake of women at midlife in baseline and prevalence of depressive symptoms 5 years later.
Women enrolled in the Study of Women's Health Across the Nation (SWAN) had measures of CES-D depression scores 5 years later and trans fatty acid intake at baseline. Logistic regression models were used to study prospective associations between trans fatty acid intake and depressive symptoms.
In overall 2376 women, baseline trans fatty acid intake did not predict depressive symptoms (p = 0.139) in model 1 adjusting for total caloric intake. However, after additional adjustment for age, race/ethnicity, education, financial strain, physical activity, BMI, menopausal status, VMS, chronic stress and use of antidepressant in model 2, baseline trans fatty acid intake predicted depressive symptoms 5 years later. This association remained statistically significant when additional controlling for SHBG, testosterone and estradiol in fully adjusted model 3. The fully adjusted OR of depressive symptoms was 1.637 (1.087-2.467) in quartile 4 (the highest) versus quartile 1 (the lowest) of the trans fatty acid intake. Sensitivity analyses performed in women with baseline CES-D score <16 showed that this association remained statistically significant.
Assessment of depression and trans fatty acid intake was based on a self-report scale.
Trans fatty acid intake is a predictor for depressive symptoms 5 years later in midlife women independent health and psychosocial profiles. This underlines the importance of targeting trans fatty acid in the prevention of major depression in midlife women.
本前瞻性研究考察了中年女性基线时饮食中反式脂肪酸的摄入量与 5 年后抑郁症状发生率之间的关系。
参加妇女健康全国研究（SWAN）的女性在 5 年后有 CES-D 抑郁评分的测量值和基线时的反式脂肪酸摄入量。使用逻辑回归模型研究反式脂肪酸摄入与抑郁症状之间的前瞻性关联。
在 2376 名女性中，在调整总热量摄入的模型 1 中，基线反式脂肪酸摄入与抑郁症状无关（p=0.139）。然而，在调整年龄、种族/族裔、教育、经济压力、体力活动、BMI、绝经状态、VMS、慢性压力和抗抑郁药使用的模型 2 后，基线反式脂肪酸摄入可预测 5 年后的抑郁症状。当在完全调整模型 3 中进一步控制 SHBG、睾酮和雌二醇时，这种关联仍然具有统计学意义。反式脂肪酸摄入最高四分位数 4 与最低四分位数 1 相比，抑郁症状的完全调整比值比为 1.637（1.087-2.467）。在基线 CES-D 评分<16 的女性中进行的敏感性分析表明，这种关联仍然具有统计学意义。
抑郁和反式脂肪酸摄入的评估是基于自我报告量表。
中年女性基线时反式脂肪酸的摄入量是 5 年后抑郁症状的预测因子，独立于健康和心理社会状况。这强调了在中年女性中针对反式脂肪酸预防重度抑郁症的重要性。
