Department of Clinical Laboratory, Renmin Hospital of Wuhan University, Wuhan 430060, China.
Department of Clinical Laboratory, Renmin Hospital of Wuhan University, Wuhan 430060, China.
J Affect Disord. 2022 Nov 15;317:91-97. doi: 10.1016/j.jad.2022.08.057. Epub 2022 Aug 27.
To study the association of Provitamin A (pro-A) carotenoid intake from diet with depressive symptoms in midlife women.
Data for this cross-sectional study were retrieved from baseline assessment of the Study of Women's Health Across the Nation (SWAN). Logistic regression and restricted cubic spline models were performed to examine the association pro-A carotenoid intake with depressive symptoms.
A total of 3054 midlife women aged 42-52 years were included in the present study. In overall midlife women, pro-A carotenoid intake was inversely associated with depressive symptoms (CES-D score ≥16). In premenopausal women, pro-A carotenoid intake was inversely associated with depressive symptoms after adjustment for age, race/ethnicity, total family income, education, physical activity, BMI, use of antidepressant, dietary total caloric, protein, carbohydrate, fat, vitamin C, vitamin E and pro-A carotenes in model 1. In fully adjusted model, after additional adjustment for day of cycle, FSH and SHBG, this association remained statistically significant. The fully adjusted odds ratios (ORs) with 95 % CI of depressive symptoms were 0.685 (0.450-1.043) in quartile 4 compared with quartile 1 for pro-A carotenoid intake. However, in early perimenopausal women, no statistically significant difference was observed between pro-A carotenoid intake and depressive symptoms after adjustment for confounders.
This was a cross-sectional study, limiting causal inferences. Assessment of CES-D was based on a self-report scale.
Pro-A carotenoid intake may be inversely associated with depression symptoms in premenopausal women, but not in early perimenopausal women.
研究饮食中类维生素 A（pro-A）类胡萝卜素摄入量与中年女性抑郁症状之间的关联。
本横断面研究的数据来自妇女健康全国研究（SWAN）的基线评估。使用逻辑回归和限制三次样条模型来检验 pro-A 类胡萝卜素摄入量与抑郁症状之间的关系。
本研究共纳入 3054 名 42-52 岁的中年女性。在所有中年女性中，pro-A 类胡萝卜素摄入量与抑郁症状呈负相关（CES-D 评分≥16）。在未绝经女性中，在调整年龄、种族/族裔、家庭总收入、教育程度、身体活动、BMI、抗抑郁药使用、膳食总热量、蛋白质、碳水化合物、脂肪、维生素 C、维生素 E 和 pro-A 类胡萝卜素后，pro-A 类胡萝卜素摄入量与抑郁症状呈负相关在模型 1 中。在完全调整模型中，在进一步调整周期天数、FSH 和 SHBG 后，这种关联仍然具有统计学意义。与 pro-A 类胡萝卜素摄入量最低四分位组（四分位 1）相比，最高四分位组（四分位 4）的抑郁症状的完全调整后比值比（OR）及其 95%置信区间（CI）为 0.685（0.450-1.043）。然而，在早期绝经前期女性中，在调整混杂因素后，pro-A 类胡萝卜素摄入量与抑郁症状之间没有观察到统计学差异。
这是一项横断面研究，限制了因果推断。CES-D 的评估是基于自我报告的量表。
在未绝经女性中，pro-A 类胡萝卜素的摄入量可能与抑郁症状呈负相关，但在早期绝经前期女性中则不然。
