Department of Clinical Laboratory, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, China.
Department of Clinical Laboratory, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, China.
J Affect Disord. 2020 Nov 1;276:914-919. doi: 10.1016/j.jad.2020.07.070. Epub 2020 Jul 20.
To study the association of manganese intake from diet with depressive symptoms in midlife women.
Data for this cross-sectional study were retrieved from baseline assessment of the Study of Women's Health Across the Nation (SWAN). Linear regression, logistic regression and restricted cubic spline models were performed to examine the association of manganese intake with depressive symptoms.
A total of 2993 midlife women aged 42-52 years were included in the present study. In premenopausal women, manganese intake was inversely associated with CES-D score and after adjustment for total caloric intake, age, race/ethnicity, education, income, financial strain, physical activity, BMI, vasomotor symptoms, chronic stress and use of antidepressant, estradiol, testosterone and sex hormone binding globulin using linear regression. The fully adjusted regression coefficient 95% confidence intervals (CIs) were -0.533 (-0.993, -0.074). Similarly, manganese intake was inversely associated with depressive symptoms (CES-D scores≥16) using logistic regression adjusted same confounders. The fully adjusted odds ratios (ORs) with 95% CI of depressive symptoms were 0.512 (0.287-0.913) in quartile 4 compared with quartile 1 for manganese intake. However, in early perimenopausal women, no statistically significant difference was observed between manganese intake and depressive symptoms after adjustment for same confounders that adjusted in premenopausal women.
This was a cross-sectional study, limiting causal inferences. Assessment of CES-D was based on a self-report scale.
Manganese intake may be inversely associated with depression symptoms in premenopausal women, but not in early perimenopausal women.
研究饮食中锰摄入与中年女性抑郁症状的关系。
本横断面研究的数据来自妇女健康全国研究（SWAN）的基线评估。采用线性回归、逻辑回归和限制三次样条模型来研究锰摄入与抑郁症状的关系。
共纳入 2993 名年龄在 42-52 岁的绝经前妇女。在绝经前妇女中，锰摄入与 CES-D 评分呈负相关，在校正总热量摄入、年龄、种族/民族、教育程度、收入、经济压力、体力活动、BMI、血管舒缩症状、慢性压力和使用抗抑郁药、雌二醇、睾酮和性激素结合球蛋白后，采用线性回归。完全调整后的回归系数 95%置信区间（CI）为-0.533（-0.993，-0.074）。同样，采用同样的混杂因素进行逻辑回归调整后，锰摄入与抑郁症状呈负相关（CES-D 评分≥16）。完全调整后的优势比（OR）及其 95%CI 为锰摄入量第 4 四分位与第 1 四分位相比，抑郁症状的 0.512（0.287-0.913）。然而，在早期绝经前妇女中，在校正绝经前妇女调整的相同混杂因素后，锰摄入与抑郁症状之间没有观察到统计学上的显著差异。
这是一项横断面研究，限制了因果推断。CES-D 的评估是基于自我报告的量表。
在绝经前妇女中，锰摄入可能与抑郁症状呈负相关，但在早期绝经前妇女中则不然。
