网络成瘾者对负性刺激的神经加工改变：与娱乐性游戏使用者比较的 fMRI 证据。
Altered neural processing of negative stimuli in people with internet gaming disorder: fMRI evidence from the comparison with recreational game users.
机构信息
Center for Cognition and Brain Disorders, The Affiliated Hospital of Hangzhou Normal University, Hangzhou 311121, Zhejiang, China.
Department of Psychology, Zhejiang Normal University, Jinhua, China.
出版信息
J Affect Disord. 2020 Mar 1;264:324-332. doi: 10.1016/j.jad.2020.01.008. Epub 2020 Jan 7.
BACKGROUND
Abundant clinical studies have suggested that emotion dysregulation seems to be the essential pathogenesis for Internet gaming disorder (IGD). However, the neural mechanism of emotion regulation for IGD is still unclear.
METHODS
Subjective evaluation and fMRI data were collected from 50 subjects (IGD: 24; recreational game user (RGU): 26) while they were performing an emotion reappraisal task. We collected and compared their brain features during emotion processing of different visual stimuli.
RESULTS
Higher activation in the left dorsal anterior cingulate cortex (dACC), right ventral ACC, left claustrum and bilateral insula was observed in participants with IGD during emotion reappraisal relative to that of the RGU participants. In addition, generalized psychophysiological interaction analysis also showed that IGD participants had stronger functional connectivity between the right insula and bilateral dorsolateral prefrontal cortex (DLPFC) than the RGU participants.
CONCLUSIONS
The results suggest that IGD participants could not down-regulate their negative emotional experiences as efficiently as the RGU participants, although they engaged more cognitive resources. These results reveal the special neural circuits of emotion dysregulation in IGD individuals and provide new neural perspective for the intervention of IGD.
背景
大量临床研究表明，情绪失调似乎是网络成瘾障碍（IGD）的重要发病机制。然而，IGD 的情绪调节的神经机制仍不清楚。
方法
从 50 名受试者（IGD：24；娱乐游戏用户（RGU）：26）中收集主观评估和 fMRI 数据，当他们执行情绪再评价任务时。我们收集并比较了他们在不同视觉刺激下情绪处理过程中的大脑特征。
结果
与 RGU 参与者相比，IGD 参与者在情绪再评价过程中，左侧背侧前扣带皮层（dACC）、右侧腹侧 ACC、左侧屏状核和双侧岛叶的激活更高。此外，广义心理生理交互分析还表明，IGD 参与者的右侧岛叶与双侧背外侧前额叶皮层（DLPFC）之间的功能连接比 RGU 参与者更强。
结论
研究结果表明，尽管 IGD 参与者动用了更多的认知资源，但他们不能像 RGU 参与者那样有效地调节自己的负面情绪体验。这些结果揭示了 IGD 个体情绪失调的特殊神经回路，为 IGD 的干预提供了新的神经视角。
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