Escuela de Medicina Veterinaria, Universidad Nacional, Campus Benjamín Núñez, Barreal de Heredia, Costa Rica.
Department of Veterinary Medicine, University of Sassari, Via Vienna 2, 07100 Sassari, Italy.
Infect Genet Evol. 2020 Jul;81:104239. doi: 10.1016/j.meegid.2020.104239. Epub 2020 Feb 11.
The limited knowledge on Papillomavirus diversity (particularly in wild animal species) influences the accuracy of PVs phylogeny and their evolutionary history, and hinders the comprehension of PVs pathogenicity, especially the mechanism of virus - related cancer progression. This study reports the identification of Leopardus wiedii Papillomavirus type 1 (LwiePV1), the first PV type within Lambdapapillomavirus in a Leopardus host. LwiePV1 full genome sequencing allowed the investigation of its taxonomic position and phylogeny. Based on results, LwiePV1 should be assigned to a novel PV species providing evidence for a polyphyletic origin of feline lambda PVs, and representing an exception to codivergence between feline lambda PVs and their hosts. Results improve our knowledge on PV diversity and pave the way to future studies investigating biological and evolutionary features of animal PVs.
关于乳头瘤病毒多样性的知识有限（尤其是在野生动物物种中），影响了 HPV 系统发生及其进化史的准确性，并阻碍了对 HPV 致病性的理解，特别是病毒相关癌症进展的机制。本研究报告了 Leopardus wiedii 乳头瘤病毒 1 型（LwiePV1）的鉴定，这是在 Leopardus 宿主中发现的第一个 Lambdapapillomavirus 乳头瘤病毒类型。对 LwiePV1 的全基因组测序允许研究其分类地位和系统发育。基于研究结果，LwiePV1 应被分配到一个新的 HPV 种属中，为猫科 lambda HPV 的多系起源提供了证据，并且代表了猫科 lambda HPV 与其宿主之间的趋同进化的例外。研究结果提高了我们对 HPV 多样性的认识，并为未来研究动物 HPV 的生物学和进化特征铺平了道路。
