Tore Gessica, Cacciotto Carla, Anfossi Antonio Giovanni, Dore Gian Mario, Antuofermo Elisabetta, Scagliarini Alessandra, Burrai Giovanni Pietro, Pau Salvatore, Zedda Maria Teresa, Masala Gerolamo, Pittau Marco, Alberti Alberto
Dipartimento di Medicina Veterinaria dell'Università degli Studi di Sassari, Via Vienna 2, 07100 Sassari, Italy.
Dipartimento di Scienze Mediche Veterinarie, Alma Mater Studiorum Università di Bologna, via Tolara di sopra 50, 40064 Ozzano Emilia (Bologna), Italy.
Vet Microbiol. 2017 May;204:151-158. doi: 10.1016/j.vetmic.2017.04.024. Epub 2017 Apr 27.
Investigating papillomavirus (PV) diversity is crucial to fully comprehend pathogenicity, genetic features, and evolution of taxa hosted by domestic and wild animal species. This study reports the identification of OaPV4, a novel ovine PV type within Deltapapillomaviruses 3. The study of OaPV4 genomic features combined to in situ hybridization and immunohistochemistry investigations allowed extrapolating several general biological features of ovine PVs, such as their cellular tropism, pathogenicity, and evolutionary history. Based on results, ovine PVs can be grouped into a polyphyletic ancient group of viruses, which splits in two main subgroups having peculiar cellular tropism and pathogenicity. Results add up to animal PV diversity and are crucial to future studies aimed to investigate the correlation between animal PV and cutaneous benign and malign proliferations.
研究乳头瘤病毒（PV）的多样性对于全面理解家养和野生动物宿主中各类病毒的致病性、遗传特征及进化过程至关重要。本研究报告了OaPV4的鉴定情况，它是δ乳头瘤病毒3属内的一种新型绵羊PV类型。对OaPV4基因组特征的研究，结合原位杂交和免疫组织化学研究，有助于推断绵羊PV的一些一般生物学特征，如细胞嗜性、致病性和进化史。基于研究结果，绵羊PV可分为一个多系的古老病毒群，该病毒群分为两个具有独特细胞嗜性和致病性的主要亚群。这些结果增加了动物PV的多样性，对于未来旨在研究动物PV与皮肤良性和恶性增殖之间相关性的研究至关重要。
