• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

African Ancestry Proportion Influences Ileal Gene Expression in Inflammatory Bowel Disease.

作者信息

Mo A, Krishnakumar C, Arafat D, Dhere T, Iskandar H, Dodd A, Prince J, Kugathasan S, Gibson G

机构信息

Center for Integrative Genomics, Georgia Institute of Technology, Atlanta, Georgia.

Department of Pediatrics, Emory University School of Medicine and Children's Healthcare of Atlanta, Atlanta, Georgia.

出版信息

Cell Mol Gastroenterol Hepatol. 2020;10(1):203-205. doi: 10.1016/j.jcmgh.2020.02.001. Epub 2020 Feb 10.

DOI:10.1016/j.jcmgh.2020.02.001
PMID:32058087
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7296223/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/246c/7296223/aa8b7ccf7df4/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/246c/7296223/d534fe3d1a8a/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/246c/7296223/aa8b7ccf7df4/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/246c/7296223/d534fe3d1a8a/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/246c/7296223/aa8b7ccf7df4/gr2.jpg

相似文献

1
African Ancestry Proportion Influences Ileal Gene Expression in Inflammatory Bowel Disease.非洲血统比例影响炎症性肠病患者回肠基因表达。
Cell Mol Gastroenterol Hepatol. 2020;10(1):203-205. doi: 10.1016/j.jcmgh.2020.02.001. Epub 2020 Feb 10.
2
Involvement of endoplasmic reticulum stress in inflammatory bowel disease: a different implication for colonic and ileal disease?内质网应激在炎症性肠病中的作用：对结肠和回肠疾病的不同意义？
PLoS One. 2011;6(10):e25589. doi: 10.1371/journal.pone.0025589. Epub 2011 Oct 18.
3
Colonic microbiota is associated with inflammation and host epigenomic alterations in inflammatory bowel disease.肠道微生物群与炎症性肠病中的炎症和宿主表观遗传改变有关。
Nat Commun. 2020 Mar 23;11(1):1512. doi: 10.1038/s41467-020-15342-5.
4
Peroxisome proliferator-activated receptor γ 2 mutation may cause a subset of ulcerative colitis.过氧化物酶体增殖物激活受体γ2突变可能导致一部分溃疡性结肠炎病例。
Pediatr Int. 2010 Oct;52(5):729-34. doi: 10.1111/j.1442-200X.2010.03195.x.
5
Expressing the differences between Crohn disease and ulcerative colitis.阐述克罗恩病和溃疡性结肠炎之间的差异。
PLoS Med. 2005 Aug;2(8):e230; quiz e304. doi: 10.1371/journal.pmed.0020230. Epub 2005 Aug 30.
6
Ileoscopy, colonoscopy, and backwash ileitis in children with inflammatory bowel disease: quid pro quo?炎症性肠病患儿的回肠镜检查、结肠镜检查及反流性回肠炎：交换条件？
J Pediatr Gastroenterol Nutr. 1987 May-Jun;6(3):325-7.
7
Whole-genome sequencing of African Americans implicates differential genetic architecture in inflammatory bowel disease.非裔美国人全基因组测序提示炎症性肠病存在不同的遗传结构。
Am J Hum Genet. 2021 Mar 4;108(3):431-445. doi: 10.1016/j.ajhg.2021.02.001. Epub 2021 Feb 17.
8
Indoleamine 2,3-dioxygenase and regulatory t cells in intestinal mucosa in children with inflammatory bowel disease.炎症性肠病患儿肠黏膜中的吲哚胺2,3-双加氧酶与调节性T细胞
J Biol Regul Homeost Agents. 2017 Jan-Mar;31(1):125-131.
9
Inflammatory bowel disease: the difference between children and adults.炎症性肠病：儿童与成人之间的差异
Inflamm Bowel Dis. 2008 Oct;14 Suppl 2:S9-11. doi: 10.1002/ibd.20560.
10
The increased mucosal mRNA expressions of complement C3 and interleukin-17 in inflammatory bowel disease.炎症性肠病中补体 C3 和白细胞介素-17 的黏膜 mRNA 表达增加。
Clin Exp Immunol. 2010 Jun;160(3):386-93. doi: 10.1111/j.1365-2249.2010.04093.x. Epub 2010 Jan 19.

引用本文的文献

1
Identifying inflammatory bowel disease subtypes: a comprehensive exploration of transcriptomic data and machine learning-based approaches.识别炎症性肠病亚型：对转录组数据和基于机器学习方法的全面探索
Therap Adv Gastroenterol. 2025 Aug 12;18:17562848251362391. doi: 10.1177/17562848251362391. eCollection 2025.
2
Extending gene set variation analysis with a reference dataset to stabilize scores.使用参考数据集扩展基因集变异分析以稳定分数。
BMC Genomics. 2025 Jul 1;26(1):596. doi: 10.1186/s12864-025-11769-6.
3
Analysis of diagnostic genes and molecular mechanisms of Crohn's disease and colon cancer based on machine learning algorithms.

本文引用的文献

1
Prediction of complicated disease course for children newly diagnosed with Crohn's disease: a multicentre inception cohort study.新诊断为克罗恩病儿童复杂疾病病程的预测：一项多中心发病队列研究。
Lancet. 2017 Apr 29;389(10080):1710-1718. doi: 10.1016/S0140-6736(17)30317-3. Epub 2017 Mar 2.
2
Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease.全基因组关联研究表明多种整合素基因的免疫激活与炎症性肠病有关。
Nat Genet. 2017 Feb;49(2):256-261. doi: 10.1038/ng.3760. Epub 2017 Jan 9.
3
Rates of hospitalization among African American and Caucasian American patients with Crohn's disease seen at a tertiary care center.
基于机器学习算法的克罗恩病和结肠癌诊断基因及分子机制分析
Sci Rep. 2024 Dec 30;14(1):31736. doi: 10.1038/s41598-024-82319-5.
4
Exploring Microbial Metabolite Receptors in Inflammatory Bowel Disease: An In Silico Analysis of Their Potential Role in Inflammation and Fibrosis.探索炎症性肠病中的微生物代谢物受体：对其在炎症和纤维化中潜在作用的计算机模拟分析
Pharmaceuticals (Basel). 2024 Apr 12;17(4):492. doi: 10.3390/ph17040492.
5
Concordant B and T Cell Heterogeneity Inferred from the Multiomic Landscape of Peripheral Blood Mononuclear Cells in a Crohn's Disease Cohort.从克罗恩病队列外周血单个核细胞的多组学格局推断出的一致B细胞和T细胞异质性
J Crohns Colitis. 2024 Apr 13;18(12):1939-56. doi: 10.1093/ecco-jcc/jjae055.
6
Oxidative stress gene expression, DNA methylation, and gut microbiota interaction trigger Crohn's disease: a multi-omics Mendelian randomization study.氧化应激基因表达、DNA 甲基化和肠道微生物群相互作用引发克罗恩病：一项多组学孟德尔随机化研究。
BMC Med. 2023 May 11;21(1):179. doi: 10.1186/s12916-023-02878-8.
7
Wnt signaling is boosted during intestinal regeneration by a CD44-positive feedback loop.Wnt 信号在肠道再生过程中通过 CD44 阳性反馈环得到增强。
Cell Death Dis. 2022 Feb 21;13(2):168. doi: 10.1038/s41419-022-04607-0.
8
Stratification of risk of progression to colectomy in ulcerative colitis via measured and predicted gene expression.通过测量和预测的基因表达对溃疡性结肠炎进行结肠切除术风险的分层。
Am J Hum Genet. 2021 Sep 2;108(9):1765-1779. doi: 10.1016/j.ajhg.2021.07.013. Epub 2021 Aug 26.
9
Altered splicing associated with the pathology of inflammatory bowel disease.与炎症性肠病病理相关的剪接改变。
Hum Genomics. 2021 Jul 23;15(1):47. doi: 10.1186/s40246-021-00347-y.
10
Increased colonic expression of ACE2 associates with poor prognosis in Crohn's disease.ACE2 在结肠中的表达增加与克罗恩病的预后不良相关。
Sci Rep. 2021 Jun 29;11(1):13533. doi: 10.1038/s41598-021-92979-2.
在一家三级医疗中心就诊的患有克罗恩病的非裔美国患者和欧裔美国患者的住院率。
Gastroenterol Rep (Oxf). 2017 Nov;5(4):288-292. doi: 10.1093/gastro/gow036. Epub 2016 Dec 10.
4
Genome-Wide Association Study Identifies African-Specific Susceptibility Loci in African Americans With Inflammatory Bowel Disease.全基因组关联研究确定了患有炎症性肠病的非裔美国人中特定于非洲人的易感基因座。
Gastroenterology. 2017 Jan;152(1):206-217.e2. doi: 10.1053/j.gastro.2016.09.032. Epub 2016 Sep 28.
5
Characterization of genetic loci that affect susceptibility to inflammatory bowel diseases in African Americans.非裔美国人中影响炎症性肠病易感性的基因位点特征分析。
Gastroenterology. 2015 Nov;149(6):1575-1586. doi: 10.1053/j.gastro.2015.07.065. Epub 2015 Aug 14.
6
National estimates of the burden of inflammatory bowel disease among racial and ethnic groups in the United States.美国不同种族和族裔群体中炎症性肠病负担的全国性估计。
J Crohns Colitis. 2014 Apr;8(4):288-95. doi: 10.1016/j.crohns.2013.09.001. Epub 2013 Sep 24.
7
Common NOD2 risk variants in African Americans with Crohn's disease are due exclusively to recent Caucasian admixture.常见的 NOD2 风险变异在非裔美国人克罗恩病患者中是由于最近的白种人混合导致的。
Inflamm Bowel Dis. 2012 Dec;18(12):2357-9. doi: 10.1002/ibd.22944. Epub 2012 Mar 22.
8
Fast model-based estimation of ancestry in unrelated individuals.基于模型的无关个体祖先快速估计
Genome Res. 2009 Sep;19(9):1655-64. doi: 10.1101/gr.094052.109. Epub 2009 Jul 31.
9
The genetic structure and history of Africans and African Americans.非洲人和非裔美国人的基因结构与历史。
Science. 2009 May 22;324(5930):1035-44. doi: 10.1126/science.1172257. Epub 2009 Apr 30.
10
Application of ancestry informative markers to association studies in European Americans.祖先信息标记在欧裔美国人关联研究中的应用。
PLoS Genet. 2008 Jan;4(1):e5. doi: 10.1371/journal.pgen.0040005.