Department of Oral Implantology, Faculty of Dental Surgery, CHU Nantes, Nantes, France.
Inserm, UMR 1238, PHY-OS, Bone Sarcomas and Remodeling of Calcified Tissues, Faculty of Medicine, University of Nantes, Nantes, France.
Clin Oral Implants Res. 2020 Jun;31(6):526-535. doi: 10.1111/clr.13589. Epub 2020 Feb 28.
It is well known that surface treatments of dental implants have a great impact on their rate of osseointegration. The aim of this study was to compare the biocompatibility and the bone-implant contact (BIC) of titanium dental implants with different surface treatments.
Test implants (Biotech Dental) had a nanostructured surface and control implants (Anthogyr) were grit-blasted with biphasic calcium phosphate and acid-etched surface. Both titanium implants were inserted in mandible and maxillary bones of 6 Yucatan minipigs for 4 and 12 weeks (n = 10 implants/group). Biocompatibility and osseointegration were evaluated by non-decalcified histology and back-scattered electron microscopy images.
The reading of histology sections by an antomo-pathologist indicated that the test implants were considered non-irritating to the surrounding tissues and thus biocompatible compared with control implants. The BIC values were higher for test than for control dental implants at both 4 and 12 weeks.
In summary, the new nanostructured titanium dental implant is considered biocompatible and showed a better osseointegration than the control implant at both 4 and 12 weeks.
众所周知，牙种植体的表面处理对其骨整合率有很大影响。本研究旨在比较不同表面处理的钛牙种植体的生物相容性和骨-种植体接触（BIC）。
测试种植体（Biotech Dental）具有纳米结构表面，对照种植体（Anthogyr）采用双相磷酸钙和酸蚀表面喷砂处理。两种钛种植体均植入 6 只尤卡坦小型猪的下颌骨和上颌骨中 4 和 12 周（每组 n=10 个种植体）。通过非脱钙组织学和背散射电子显微镜图像评估生物相容性和骨整合。
病理学家对组织学切片的阅读表明，与对照种植体相比，测试种植体被认为对周围组织无刺激性，因此具有生物相容性。在 4 和 12 周时，测试种植体的 BIC 值均高于对照种植体。
总之，新型纳米结构钛牙种植体被认为具有生物相容性，在 4 和 12 周时与对照种植体相比，具有更好的骨整合。
