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发光二极管光生物调节对牙种植体骨结合的影响：一项体内研究。

Effect of LED photobiomodulation on dental implant osseointegration: An in vivo study.

作者信息

Foletti Jean-Marc, Remy Floriane, Chevenement Luc, Sterba Manon, Tavitian Patrick, Badih Laurent, Kenck-Veran Olivia

机构信息

Department of Oral and maxillofacial Surgery, APHM, Conception University Hospital, Marseille, France.

Aix-Marseille Univ, Gustave Eiffel Univ, LBA, Marseille, France.

出版信息

J Dent Res Dent Clin Dent Prospects. 2023 Winter;17(1):28-34. doi: 10.34172/joddd.2023.36954. Epub 2023 Apr 3.

DOI:10.34172/joddd.2023.36954
PMID:37650019
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10462914/
Abstract

BACKGROUND

Photobiomodulation (PBM) may be prescribed after dental surgery to accelerate tissue healing and improve implant stability. The objective of this study is to evaluate the efficiency of LED-PBM on the dental implant osseointegration.

METHODS

A total of 48 implants (Kontact) were inserted in 8 Yucatan minipigs (6 implants per minipig) divided into 2 groups (test and control). The test group received LED-PBM with a total energy of 124.2 J/cm delivered over 4 sessions (at day0, day+8, day+15 and day+28) lasting 12 minutes each. At day+28, all animals were sacrificed, and their mandibles removed to perform histologic and histomorphometric analysis. Implant osseointegration was evaluated using the computation of bone/implant contact (BIC) index and bone surface/total surface (BS/ TS) ratio. The groups were compared using Student's unpaired test.

RESULTS

BIC index and BS/TS ratio were significantly higher within the test group as compared to the control group (<0.01). Histologic observations on bone tissues demonstrated that LED-PBM may improve and accelerate dental implant osseointegration: 25% of dental implants analyzed within the test group were completely osseointegrated, versus 12.5% within the control group.

CONCLUSION

This experimental study indicates that LED-PBM contributes to enhancing implant treatment outcomes.

摘要

背景

光生物调节作用（PBM）可在牙科手术后使用，以加速组织愈合并提高种植体稳定性。本研究的目的是评估发光二极管光生物调节作用（LED-PBM）对牙种植体骨整合的效果。

方法

将48颗种植体（Kontact）植入8只尤卡坦小型猪体内（每只小型猪植入6颗种植体），分为2组（试验组和对照组）。试验组接受LED-PBM治疗，总能量为124.2 J/cm，分4次进行（在第0天、第8天、第15天和第28天），每次持续12分钟。在第28天，处死所有动物，取下下颌骨进行组织学和组织形态计量学分析。通过计算骨/种植体接触（BIC）指数和骨表面积/总表面积（BS/TS）比值来评估种植体的骨整合情况。使用学生非配对t检验对两组进行比较。

结果

与对照组相比，试验组的BIC指数和BS/TS比值显著更高（<0.01）。对骨组织的组织学观察表明，LED-PBM可改善并加速牙种植体的骨整合：试验组中分析的25%牙种植体完全骨整合，而对照组为12.5%。

结论

本实验研究表明，LED-PBM有助于提高种植治疗效果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d6a3/10462914/959c8a237163/joddd-17-28-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d6a3/10462914/218307b7b454/joddd-17-28-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d6a3/10462914/23686592d004/joddd-17-28-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d6a3/10462914/f2e37f540741/joddd-17-28-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d6a3/10462914/9c42938678bd/joddd-17-28-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d6a3/10462914/959c8a237163/joddd-17-28-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d6a3/10462914/218307b7b454/joddd-17-28-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d6a3/10462914/23686592d004/joddd-17-28-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d6a3/10462914/f2e37f540741/joddd-17-28-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d6a3/10462914/9c42938678bd/joddd-17-28-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d6a3/10462914/959c8a237163/joddd-17-28-g005.jpg

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