University of Toronto, Toronto, Canada.
The Hospital for Sick Children and University of Toronto, 555 University Ave, Toronto, ON, M5G 1X8, Canada.
Clin Drug Investig. 2020 Apr;40(4):293-304. doi: 10.1007/s40261-020-00894-7.
The legalisation of cannabis in a growing number of jurisdictions has led to increasing interest in its potential therapeutic effects in a range of disorders, including cutaneous conditions. Cannabinoids have been used as natural medicines for centuries; however, their biological activity in the skin is a new area of study. Recent data suggest that cannabinoids are involved in neuro-immuno-endocrine modulation of skin functioning, yet their effect on the features of dermatologic conditions is unclear. This article sought to review the mechanisms by which cannabinoids regulate skin functioning through the lens of relevance to treatment of dermatologic diseases looking at the effects of cannabinoids on a range of cellular activities and dermatologic conditions both in vitro and in vivo. We identified studies demonstrating an inhibitory effect of cannabinoids on skin inflammation, proliferation, fibrosis, pain, and itch-biological mechanisms involved in the pathogenesis of many dermatologic conditions. Cannabinoids have the potential to expand the therapeutic repertoire of a wide spectrum of skin disorders. Given their widespread unregulated use by the general public, basic and clinical studies are required to elucidate the effectiveness and long-term effects of topical and systemic cannabinoids in cutaneous disorders.
大麻在越来越多的司法管辖区合法化，导致人们对其在一系列疾病（包括皮肤疾病）中的潜在治疗作用越来越感兴趣。大麻素作为天然药物已经使用了几个世纪；然而，它们在皮肤中的生物活性是一个新的研究领域。最近的数据表明，大麻素参与皮肤功能的神经免疫内分泌调节，但它们对皮肤疾病特征的影响尚不清楚。本文试图通过研究大麻素对各种细胞活动和皮肤疾病的影响，从治疗皮肤病的角度来探讨大麻素调节皮肤功能的机制，着眼于大麻素对这些疾病的作用。我们发现了一些研究表明，大麻素对皮肤炎症、增殖、纤维化、疼痛和瘙痒具有抑制作用，这些生物学机制涉及许多皮肤病的发病机制。大麻素有可能扩大广泛的皮肤疾病的治疗范围。鉴于大麻素在普通民众中广泛不受监管地使用，需要进行基础和临床研究，以阐明局部和全身使用大麻素在皮肤疾病中的有效性和长期效果。
