果蝇胚胎中枢神经系统发育过程中 Notch 信号的五种形态。

The Five Faces of Notch Signalling During Drosophila melanogaster Embryonic CNS Development.

机构信息

The Hospital for Sick Children, Peter Gilgan Center for Research and Learning, Toronto, ON, Canada.

Karolinska Institutet, Department of Cell and Molecular Biology (CMB), Stockholm, Sweden.

出版信息

Adv Exp Med Biol. 2020;1218:39-58. doi: 10.1007/978-3-030-34436-8_3.

DOI:10.1007/978-3-030-34436-8_3

PMID:32060870

Abstract

During central nervous system (CNS) development, a complex series of events play out, starting with the establishment of neural progenitor cells, followed by their asymmetric division and formation of lineages and the differentiation of neurons and glia. Studies in the Drosophila melanogaster embryonic CNS have revealed that the Notch signal transduction pathway plays at least five different and distinct roles during these events. Herein, we review these many faces of Notch signalling and discuss the mechanisms that ensure context-dependent and compartment-dependent signalling. We conclude by discussing some outstanding issues regarding Notch signalling in this system, which likely have bearing on Notch signalling in many species.

摘要

在中枢神经系统（CNS）发育过程中，一系列复杂的事件相继发生，首先是神经祖细胞的建立，随后是它们的不对称分裂以及谱系的形成，最后是神经元和神经胶质的分化。在黑腹果蝇胚胎中枢神经系统的研究中表明，Notch 信号转导途径在这些事件中至少发挥了五种不同且独特的作用。在此，我们将回顾 Notch 信号转导的这些多方面作用，并讨论确保依赖上下文和依赖隔室的信号转导的机制。最后，我们将讨论关于该系统中 Notch 信号转导的一些悬而未决的问题，这些问题可能对许多物种中的 Notch 信号转导具有重要意义。