State Key Laboratory of Chemical Engineering, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, PR China.
State Key Laboratory of Chemical Engineering, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, PR China.
J Control Release. 2020 May 10;321:236-258. doi: 10.1016/j.jconrel.2020.02.014. Epub 2020 Feb 13.
Diabetes, as a global threat nowadays, causes the wide usage of exogenous insulin. Subcutaneous injection is the traditional insulin administration in the diabetes treatments and is inconvenient and painful, which results in potential side effects of hypoglycemia. Scientists have made great efforts to develop alternatives. As the promising solutions, smart insulin delivery systems fabricated with glucose- responsive compounds attract considerable attention in the field of diabetes treatments. This review discusses the classifications, properties, response mechanisms of the glucose-responsive compounds, glucose oxidase and concanavalin A and recent progress of glucose-responsive insulin delivery systems.
糖尿病作为当今全球的一大威胁，导致了外源性胰岛素的广泛使用。皮下注射是糖尿病治疗中传统的胰岛素给药方式，但这种方式既不方便也很痛苦，还可能导致低血糖等潜在副作用。为了寻找替代方案，科学家们付出了巨大努力。具有葡萄糖响应性化合物的智能胰岛素输送系统作为有前途的解决方案，在糖尿病治疗领域引起了广泛关注。本文综述了葡萄糖响应性化合物、葡萄糖氧化酶和伴刀豆球蛋白 A 的分类、性质、响应机制以及葡萄糖响应型胰岛素输送系统的最新进展。
