State Key Laboratory of Chemical Engineering, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, PR China.
State Key Laboratory of Chemical Engineering, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, PR China.
J Control Release. 2018 Oct 28;288:173-188. doi: 10.1016/j.jconrel.2018.08.042. Epub 2018 Sep 3.
Microneedle technology relates to pharmacy, polymer chemistry and micromachining. Microneedle can effectively deliver insulin into systemic circulation across the skin. This process does not affect the activity of insulin. Compared to subcutaneous injection, microneedles cause less pain for their special structure. This review thoroughly discusses the preparation technologies of the microneedles-based insulin delivery system including solid, hollow, dissolving, phase transition, glucose-responsive microneedle patches. In the meantime, the properties, challenges and clinical/commercial status of the microneedles-based insulin delivery system are also discussed in this review.
微针技术涉及药学、聚合物化学和微机械加工。微针可以有效地将胰岛素递送至皮肤穿过的全身循环。这一过程不会影响胰岛素的活性。与皮下注射相比，由于其特殊的结构，微针引起的疼痛较小。本综述全面讨论了基于微针的胰岛素传递系统的制备技术，包括固体、空心、溶解、相转变、葡萄糖响应型微针贴片。同时，本综述还讨论了基于微针的胰岛素传递系统的性质、挑战和临床/商业现状。
