Dept. of Experimental Medicine, Sapienza University of Rome, Rome, Italy.
Dept. of Experimental Medicine, Sapienza University of Rome, Rome, Italy.
Biochimie. 2020 Jun;173:12-16. doi: 10.1016/j.biochi.2020.02.006. Epub 2020 Feb 13.
The short, non-coding RNAs, also called microRNAs (miRNAs) can bind complementary sequences on cellular mRNAs. The consequence of this binding is generally the degradation of mRNA and the inhibition of its translation. For this reason, miRNAs are included among the epigenetic factors acting as a modulator of gene expression. How miRNAs expression is, in turn, regulated is still the object of active investigation, but DNA methylation, another epigenetic modification, seems to play a central role in this sense. The "one-carbon" metabolism is responsible for the metabolic regulation of trans-methylation reactions and, therefore, DNA methylation. For this reason, to investigate the possible correlations between alterations of the one-carbon metabolism and differential DNA methylation sounds interesting. Moreover, recent evidence indicates that, vice-versa, miRNAs are associated with DNA methylation modulation, in a mutual cross-talk. The present review will discuss the interplay between miRNAs and DNA methylation and its fall-out on gene expression regulation.
短链非编码 RNA，也被称为 microRNAs（miRNAs），可以与细胞 mRNA 上的互补序列结合。这种结合的结果通常是 mRNA 的降解和翻译的抑制。因此，miRNAs 被归入作为基因表达调节剂的表观遗传因子。miRNAs 的表达是如何被调节的，仍然是一个活跃的研究对象，但 DNA 甲基化，另一种表观遗传修饰，似乎在这方面起着核心作用。“一碳”代谢负责转甲基反应和 DNA 甲基化的代谢调节。因此，研究一碳代谢的改变与差异 DNA 甲基化之间的可能相关性是很有趣的。此外，最近的证据表明，反过来，miRNAs 与 DNA 甲基化的调节有关，在相互交叉对话中。本综述将讨论 miRNA 和 DNA 甲基化之间的相互作用及其对基因表达调控的影响。
