结扎涎腺导管后再生涎腺与胚胎涎腺的形态学差异。

Morphological differences between regenerating salivary glands after salivary gland duct ligation and embryonic salivary glands.

机构信息

Department of Oral-facial Disorders, Osaka University Graduate School of Dentistry, Osaka, Japan; Research Fellow of Japan Society for the Promotion of Science, Japan.

Department of Oral Pathology, Osaka University Graduate School of Dentistry, Osaka, Japan.

出版信息

Ann Anat. 2020 May;229:151482. doi: 10.1016/j.aanat.2020.151482. Epub 2020 Feb 13.

DOI:10.1016/j.aanat.2020.151482

PMID:32061835

Abstract

BACKGROUND

Most animals and organs have regenerative capabilities. Whether regeneration is a developmental process or a distinct phenomenon that is independent of development is debatable.

METHOD

We examined the differences between developing and regenerating salivary glands using duct-ligation models. We performed morphological analyses comparing submandibular gland regeneration and development. To reveal the proliferation processes that occur during salivary gland regeneration and development, we counted the number of Ki67-positive cells over time. In addition, we examined the expression of the following markers: aquaporin 5, smooth muscle actin, cytokeratin 7, and tubulin beta 3.

RESULT

The proliferation patterns seen during regeneration differed from those observed during development. Different salivary gland marker expression patterns were seen during development and regeneration.

CONCLUSION

This study showed that regenerating salivary glands do not follow the same growth process as developing salivary glands.

摘要

背景

大多数动物和器官都具有再生能力。再生是一种发育过程还是一种独立于发育的独特现象，这是有争议的。

方法

我们使用导管结扎模型研究了发育中的唾液腺和再生中的唾液腺之间的差异。我们进行了形态学分析，比较了颌下腺的再生和发育。为了揭示唾液腺再生和发育过程中的增殖过程，我们随时间计数 Ki67 阳性细胞的数量。此外，我们还检查了以下标记物的表达：水通道蛋白 5、平滑肌肌动蛋白、细胞角蛋白 7 和微管蛋白β 3。