Department of Pharmaceutics, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Ooty, The Nilgiris, Tamil Nadu, India.
Department of Pharmacology, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Ooty, The Nilgiris, Tamil Nadu, India; Department of Pharmacology, School of Pharmaceutical Sciences & Technologies, JNT University Kakinada, Kakinada, Andhra Pradesh, India.
Int J Biol Macromol. 2020 May 1;150:631-636. doi: 10.1016/j.ijbiomac.2020.02.131. Epub 2020 Feb 13.
The present research reports the beneficial effects of surface modified chitosan and tumor-homing peptide conjugated liposomes of capecitabine (CAP) for treating breast cancer. Liposomal formulation of CAP was prepared by film hydration method using cholesterol-THP conjugate (CTHP-CAP-LPs) to achieve active targeting through HER2 receptors. CTHP-CAP-LPs significantly improved the specificity and efficacy of CAP by improving cell uptake, cytotoxicity and tumor regression in tumor bearing mice. CTHP-CAP-LPs, therefore, is a promising approach to improve the anticancer effects of CAP.
本研究报告了表面修饰壳聚糖和肿瘤归巢肽偶联卡培他滨（CAP）脂质体治疗乳腺癌的有益效果。通过使用胆固醇-THP 轭合物（CTHP-CAP-LPs）的薄膜水化法制备 CAP 的脂质体制剂，以通过 HER2 受体实现主动靶向。CTHP-CAP-LPs 通过提高细胞摄取、细胞毒性和荷瘤小鼠的肿瘤消退，显著提高了 CAP 的特异性和疗效。因此，CTHP-CAP-LPs 是提高 CAP 抗癌效果的一种有前途的方法。
