• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

用于改善乳腺癌细胞凋亡活性及HER2靶向治疗的肿瘤归巢肽修饰的卡培他滨脂质体：研究

Tumor homing peptide modified liposomes of capecitabine for improved apoptotic activity and HER2 targeted therapy in breast cancer: studies.

作者信息

Singh Mantosh Kumar, Pindiprolu Sai Kiran S S, Reddy Sanapalli Bharat Kumar, Yele Vidyasrilekha, Ganesh G N K

机构信息

Department of Pharmaceutics, JSS College of Pharmacy, Ooty, JSS Academy of Higher Education & Research India

Department of Pharmacology, JSS College of Pharmacy, Ooty, JSS Academy of Higher Education & Research India.

出版信息

RSC Adv. 2019 Aug 12;9(43):24987-24994. doi: 10.1039/c9ra04814f. eCollection 2019 Aug 8.

DOI:10.1039/c9ra04814f
PMID:35528678
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9070003/
Abstract

In the present study, we have formulated a liposomal formulation of cytotoxic agent capecitabine (CAP) to overcome its bioavailability issues. Then we have surface modified CAP loaded liposomes (CAP-LPs) with a tumour homing peptide (THP-CAP-LPs) to achieve site specific delivery to breast cancer cells. We found a significant cellular internalization of THP-CAP-LPs when compared to unmodified CAP-LPs. The cytotoxic effect of CAP was also significantly improved with THP-CAP-LPs by downregulating anti-apoptotic proteins and upregulating pro-apoptotic proteins as observed by Western blot analysis. THP-CAP-LPs mediated delivery of CAP can be, therefore, a promising approach for improving antitumor activity and reducing off-target effects.

摘要

在本研究中，我们制备了细胞毒性药物卡培他滨（CAP）的脂质体制剂，以克服其生物利用度问题。然后，我们用肿瘤归巢肽对负载CAP的脂质体（CAP-LPs）进行了表面修饰（THP-CAP-LPs），以实现对乳腺癌细胞的位点特异性递送。我们发现，与未修饰的CAP-LPs相比，THP-CAP-LPs在细胞内的摄取显著增加。通过蛋白质免疫印迹分析观察到，THP-CAP-LPs还通过下调抗凋亡蛋白和上调促凋亡蛋白，显著提高了CAP的细胞毒性作用。因此，THP-CAP-LPs介导的CAP递送可能是一种改善抗肿瘤活性和减少脱靶效应的有前景的方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/468f/9070003/fcb7565e6f29/c9ra04814f-f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/468f/9070003/6fe57c4063c6/c9ra04814f-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/468f/9070003/8b421380af06/c9ra04814f-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/468f/9070003/18f8d4a550c7/c9ra04814f-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/468f/9070003/c5ec4afb880f/c9ra04814f-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/468f/9070003/7df3254eba3f/c9ra04814f-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/468f/9070003/d5f1ceb86bd6/c9ra04814f-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/468f/9070003/8638f0f076ec/c9ra04814f-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/468f/9070003/fcb7565e6f29/c9ra04814f-f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/468f/9070003/6fe57c4063c6/c9ra04814f-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/468f/9070003/8b421380af06/c9ra04814f-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/468f/9070003/18f8d4a550c7/c9ra04814f-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/468f/9070003/c5ec4afb880f/c9ra04814f-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/468f/9070003/7df3254eba3f/c9ra04814f-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/468f/9070003/d5f1ceb86bd6/c9ra04814f-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/468f/9070003/8638f0f076ec/c9ra04814f-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/468f/9070003/fcb7565e6f29/c9ra04814f-f8.jpg

相似文献

1
Tumor homing peptide modified liposomes of capecitabine for improved apoptotic activity and HER2 targeted therapy in breast cancer: studies.用于改善乳腺癌细胞凋亡活性及HER2靶向治疗的肿瘤归巢肽修饰的卡培他滨脂质体：研究
RSC Adv. 2019 Aug 12;9(43):24987-24994. doi: 10.1039/c9ra04814f. eCollection 2019 Aug 8.
2
HER2 targeted biological macromolecule modified liposomes for improved efficacy of capecitabine in breast cancer.曲妥珠单抗靶向生物大分子修饰脂质体提高卡培他滨在乳腺癌中的疗效。
Int J Biol Macromol. 2020 May 1;150:631-636. doi: 10.1016/j.ijbiomac.2020.02.131. Epub 2020 Feb 13.
3
RAGE receptor targeted bioconjuguate lipid nanoparticles of diallyl disulfide for improved apoptotic activity in triple negative breast cancer: in vitro studies.二烯丙基二硫靶向受体的脂质纳米载体用于改善三阴性乳腺癌的凋亡活性：体外研究。
Artif Cells Nanomed Biotechnol. 2018 Mar;46(2):387-397. doi: 10.1080/21691401.2017.1313267. Epub 2017 Apr 17.
4
Tuftsin-Bearing Liposomes Co-Encapsulated with Doxorubicin and Curcumin Efficiently Inhibit EAC Tumor Growth in Mice.共包封阿霉素和姜黄素的含促吞噬肽脂质体可有效抑制小鼠艾氏腹水癌肿瘤生长。
Int J Nanomedicine. 2020 Dec 31;15:10547-10559. doi: 10.2147/IJN.S276336. eCollection 2020.
5
Development of synthetic peptide-modified liposomes with LDL receptor targeting capacity and improved anticancer activity.具有低密度脂蛋白受体靶向能力及增强抗癌活性的合成肽修饰脂质体的研发。
Mol Pharm. 2014 Jul 7;11(7):2305-12. doi: 10.1021/mp400759d. Epub 2014 Jun 3.
6
Tumor targeting using anti-her2 immunoliposomes.使用抗HER2免疫脂质体进行肿瘤靶向
J Control Release. 2001 Jul 6;74(1-3):95-113. doi: 10.1016/s0168-3659(01)00315-7.
7
PNA-Modified Liposomes Improve the Delivery Efficacy of CAPIRI for the Synergistic Treatment of Colorectal Cancer.肽核酸修饰的脂质体提高CAPIRI方案对结直肠癌的协同治疗递送效果。
Front Pharmacol. 2022 Jun 15;13:893151. doi: 10.3389/fphar.2022.893151. eCollection 2022.
8
Engineered breast tumor targeting peptide ligand modified liposomal doxorubicin and the effect of peptide density on anticancer activity.工程化的乳腺癌靶向肽配体修饰的脂质体阿霉素及其肽密度对抗癌活性的影响。
Biomaterials. 2013 May;34(16):4089-4097. doi: 10.1016/j.biomaterials.2013.02.019. Epub 2013 Mar 5.
9
A systemically administered detoxified TLR4 agonist displays potent antitumor activity and an acceptable tolerance profile in preclinical models.一种全身性给药的 TLR4 激动剂在临床前模型中显示出强大的抗肿瘤活性和可接受的耐受谱。
Front Immunol. 2023 May 8;14:1066402. doi: 10.3389/fimmu.2023.1066402. eCollection 2023.
10
Transporter occluded-state conformation-induced endocytosis: Amino acid transporter ATB-mediated tumor targeting of liposomes for docetaxel delivery for hepatocarcinoma therapy.载体封闭状态构象诱导内吞作用：氨基酸转运体 ATB 介导的脂质体肿瘤靶向用于肝癌治疗的多西紫杉醇递送。
J Control Release. 2016 Dec 10;243:370-380. doi: 10.1016/j.jconrel.2016.10.031. Epub 2016 Nov 1.

引用本文的文献

1
Novel thiazole derivatives as effective anti-cancer agents against human osteosarcoma cell line (SaOS-2): Microwave-assisted one-pot three-component synthesis, in vitro anti-cancer studies, and in silico investigations.新型噻唑衍生物作为抗人骨肉瘤细胞系（SaOS-2）的有效抗癌剂：微波辅助一锅三组分合成、体外抗癌研究及计算机模拟研究
PLoS One. 2025 Aug 26;20(8):e0328221. doi: 10.1371/journal.pone.0328221. eCollection 2025.
2
Nanocarrier-mediated modulation of cGAS-STING signaling pathway to disrupt tumor microenvironment.纳米载体介导的cGAS-STING信号通路调节以破坏肿瘤微环境
Naunyn Schmiedebergs Arch Pharmacol. 2025 Feb 5. doi: 10.1007/s00210-025-03835-3.
3

本文引用的文献

1
Formulation-optimization of solid lipid nanocarrier system of STAT3 inhibitor to improve its activity in triple negative breast cancer cells.STAT3 抑制剂固体脂质纳米载体系统的配方优化，以提高其在三阴性乳腺癌细胞中的活性。
Drug Dev Ind Pharm. 2019 Feb;45(2):304-313. doi: 10.1080/03639045.2018.1539496. Epub 2018 Nov 8.
2
Nanocarrier based approaches for targeting breast cancer stem cells.基于纳米载体的靶向乳腺癌干细胞策略。
Artif Cells Nanomed Biotechnol. 2018 Aug;46(5):885-898. doi: 10.1080/21691401.2017.1366337. Epub 2017 Aug 21.
3
Improved anti-tumor activity of oxaliplatin by encapsulating in anti-DR5 targeted gold nanoparticles.
Peptides Targeting HER2-Positive Breast Cancer Cells and Applications in Tumor Imaging and Delivery of Chemotherapeutics.
靶向HER2阳性乳腺癌细胞的肽及其在肿瘤成像和化疗药物递送中的应用。
Nanomaterials (Basel). 2023 Sep 1;13(17):2476. doi: 10.3390/nano13172476.
4
Functionalized liposomes for targeted breast cancer drug delivery.用于靶向乳腺癌药物递送的功能化脂质体。
Bioact Mater. 2023 Jan 2;24:401-437. doi: 10.1016/j.bioactmat.2022.12.027. eCollection 2023 Jun.
5
Nanocarriers for Biomedicine: From Lipid Formulations to Inorganic and Hybrid Nanoparticles.生物医学中的纳米载体：从脂质制剂到无机及混合纳米颗粒
Int J Mol Sci. 2021 Jun 30;22(13):7055. doi: 10.3390/ijms22137055.
通过包裹于抗DR5靶向金纳米颗粒提高奥沙利铂的抗肿瘤活性。
Drug Deliv. 2016 Nov;23(9):3505-3519. doi: 10.1080/10717544.2016.1199606. Epub 2016 Jul 18.
4
Application of quality-by-design approach to optimize diallyl disulfide-loaded solid lipid nanoparticles.采用质量源于设计方法优化负载二烯丙基二硫化物的固体脂质纳米粒。
Artif Cells Nanomed Biotechnol. 2017 May;45(3):474-488. doi: 10.3109/21691401.2016.1173046. Epub 2016 Apr 25.
5
Oxaliplatin immunohybrid nanoparticles in vitro synergistic suppression evaluation in treatment of colorectal cancer.奥沙利铂免疫杂交纳米颗粒治疗结直肠癌的体外协同抑制评估
Artif Cells Nanomed Biotechnol. 2017 Mar;45(2):261-269. doi: 10.3109/21691401.2016.1146730. Epub 2016 Mar 2.
6
Enhancing activity of artesunate against breast cancer cells via induced-apoptosis pathway by loading into lipid carriers.通过装入脂质载体增强青蒿琥酯对乳腺癌细胞的活性，诱导细胞凋亡途径。
Artif Cells Nanomed Biotechnol. 2016 Dec;44(8):1979-1987. doi: 10.3109/21691401.2015.1129616. Epub 2016 Jan 11.
7
Folate-modified lipid-polymer hybrid nanoparticles for targeted paclitaxel delivery.用于靶向递送紫杉醇的叶酸修饰脂质-聚合物杂化纳米粒
Int J Nanomedicine. 2015 Mar 16;10:2101-14. doi: 10.2147/IJN.S77667. eCollection 2015.
8
RAGE mediates S100A7-induced breast cancer growth and metastasis by modulating the tumor microenvironment.晚期糖基化终末产物受体通过调节肿瘤微环境介导S100A7诱导的乳腺癌生长和转移。
Cancer Res. 2015 Mar 15;75(6):974-85. doi: 10.1158/0008-5472.CAN-14-2161. Epub 2015 Jan 8.
9
Methoxy poly(ethylene glycol)-poly(lactide) nanoparticles encapsulating quercetin act as an effective anticancer agent by inducing apoptosis in breast cancer.包裹槲皮素的甲氧基聚（乙二醇）-聚（丙交酯）纳米颗粒通过诱导乳腺癌细胞凋亡而作为一种有效的抗癌剂。
Pharm Res. 2015 Feb;32(2):723-35. doi: 10.1007/s11095-014-1504-2. Epub 2014 Sep 4.
10
Cancer active targeting by nanoparticles: a comprehensive review of literature.纳米颗粒对癌症的主动靶向：文献综述
J Cancer Res Clin Oncol. 2015 May;141(5):769-84. doi: 10.1007/s00432-014-1767-3. Epub 2014 Jul 9.