SIBS-Zhejiang Gongshang University Joint Centre for Food and Nutrition Sciences, Zhejiang Gongshang University, Hangzhou 310012, China.
SIBS-Zhejiang Gongshang University Joint Centre for Food and Nutrition Sciences, Zhejiang Gongshang University, Hangzhou 310012, China.
Int J Biol Macromol. 2020 May 15;151:781-786. doi: 10.1016/j.ijbiomac.2020.02.105. Epub 2020 Feb 13.
Bioactives can impact food function either by their dosage or by their forms of dispersion, though the latter remains mostly neglected. Here we report the incidental nanoparticles (iNPs) carrying hepatoprotective bioactives identified in freshwater clam (Corbicula fluminea Muller) soup, which is a folk remedy for liver conditions in East Asia. The soup was fractionated into two iNPs containing fractions with high yield (95.8%) in 35 min by gel chromatography. With hydrodynamic diameter (D) range from 40 nm to 149 nm, iNPs were mainly constituted by carbohydrates and proteins. Notably, the majority of bioactives, e.g. taurine (63.2%), ornithine (68.1%) and phytosterols (60.0%), was determined to be carried by the iNPs. It suggested a possible mechanism of elevated delivery and absorption of bioactives, explaining why the clam soup can work at the bioactive concentrations way lower than the individual compound. These iNPs have great potential to be developed into a functional food with most potent nutraceutical effects.
生物活性物质可以通过剂量或分散形式来影响食品功能，尽管后者在很大程度上被忽视了。在这里，我们报告了在淡水贻贝（Corbicula fluminea Muller）汤中发现的具有保肝作用的偶然纳米颗粒（iNPs），贻贝汤是东亚地区治疗肝脏疾病的民间疗法。该汤通过凝胶色谱法在 35 分钟内分离成两个产量高（95.8%）的 iNPs 含分数。iNPs 的流体力学直径（D）范围从 40nm 到 149nm，主要由碳水化合物和蛋白质组成。值得注意的是，大多数生物活性物质，如牛磺酸（63.2%）、鸟氨酸（68.1%）和植物甾醇（60.0%），被确定由 iNPs 携带。这表明生物活性物质的递送和吸收可能存在一种提升机制，解释了为什么贻贝汤可以在比单一化合物低得多的生物活性浓度下发挥作用。这些 iNPs 很有潜力被开发成具有最强营养效果的功能性食品。
