Citti Cinzia, Linciano Pasquale, Cannazza Giuseppe
Mediteknology, Spin-off of the National Council of Research, Via Arnesano, 73100 Lecce, Italy; CNR NANOTEC, Institute of Nanotechnology, Via Monteroni, 73100, Lecce, Italy; Department of Life Sciences, University of Modena and Reggio Emilia, Via G. Campi 103, 41125 Modena, Italy.
Department of Life Sciences, University of Modena and Reggio Emilia, Via G. Campi 103, 41125 Modena, Italy.
Drug Discov Today. 2020 Apr;25(4):628-632. doi: 10.1016/j.drudis.2020.02.001. Epub 2020 Feb 13.
Cannabidiol (CBD) is the main cannabinoid naturally occurring in hemp. It has recently attracted the attention of the scientific community because of its numerous pharmacological activities. However, its legal status changes depending on whether it is chemically synthesized or extracted from the plant: extracted CBD is a scheduled controlled substance, whereas synthetic CBD is not under control. In Europe, extracted CBD is excluded from the cosmetic ingredients of the CosIng database. Given the confusion surrounding these different forms of CBD, there is an urgent need for clarity to shed light from both a regulatory and a chemical point of view. The impurity profiles of synthetic and natural CBD are different and could currently represent the only means to distinguish the origin of this substance.
大麻二酚（CBD）是大麻中天然存在的主要大麻素。由于其众多的药理活性，它最近引起了科学界的关注。然而，其法律地位因是化学合成还是从植物中提取而有所不同：提取的CBD是一种列入清单的管制物质，而合成CBD则不受管制。在欧洲，提取的CBD被排除在CosIng数据库的化妆品成分之外。鉴于围绕这些不同形式的CBD存在混淆，迫切需要从监管和化学角度进行澄清以阐明情况。合成CBD和天然CBD的杂质谱不同，目前可能是区分该物质来源的唯一手段。
