School of Undergraduate Studies, DGIST, Daegu, 42988, Korea.
Department of Chemistry, Green-Nano Materials Research Center, Kyungpook National University, Daegu, 41566, Korea.
Chem Asian J. 2019 Nov 4;14(21):3749-3762. doi: 10.1002/asia.201901179. Epub 2019 Oct 8.
(-)-Cannabidiol ((-)-CBD), a non-psychoactive phytocannabinoid from Cannabis, and its structural analogs have received growing attention in recent years because of their potential therapeutic benefits, including neuroprotective, anti-epileptic, anti-inflammatory, anxiolytic, and anti-cancer properties. (-)-CBD and its analogs have been obtained mainly based on extraction from the natural source; however, the conventional extraction-based methods have some drawbacks, such as poor quality control along with purification difficulty. Chemical-synthetic strategies for (-)-CBD could tackle these issues, and, additionally, generate novel (-)-CBD analogs that exhibit advanced biological activities. This review concisely summarizes the historic and recent milestones in the synthetic strategies for (-)-CBD and its analogs.
(-)-大麻二酚((-)-CBD)是一种来自大麻的非精神活性植物大麻素，及其结构类似物近年来受到越来越多的关注，因为它们具有潜在的治疗益处，包括神经保护、抗癫痫、抗炎、抗焦虑和抗癌特性。(-)-CBD 和它的类似物主要是基于从天然来源中提取获得的；然而，传统的基于提取的方法存在一些缺点，例如质量控制不佳以及提纯困难。(-)-CBD 的化学合成策略可以解决这些问题，并且还可以生成具有先进生物活性的新型(-)-CBD 类似物。本文简要总结了(-)-CBD 及其类似物的合成策略的历史和近期里程碑。
