Servatan Morteza, Zarrintaj Payam, Mahmodi Ghader, Kim Seok-Jhin, Ganjali Mohammad Reza, Saeb Mohammad Reza, Mozafari Masoud
Polymer Engineering Department, Faculty of Engineering, Urmia University, Urmia, Iran.
School of Chemical Engineering, Oklahoma State University, Stillwater, OK, USA.
Drug Discov Today. 2020 Apr;25(4):642-656. doi: 10.1016/j.drudis.2020.02.005. Epub 2020 Feb 13.
There are continuing attempts to achieve appropriate controlled-release therapeutic systems by designing innovative functional drug delivery systems (DDS). Although various types of delivery system have been developed, strategies that have successfully made it to the clinic are rare. Given their diverse structures, zeolites have attracted significant research attention for controlled and targeted drug delivery purposes. The structure of zeolites can be microporous, mesoporous or macroporous, which can be exploited to deliver a variety of therapeutic agents to the target site in a controlled manner. In this review, we introduce the different types of zeolite, and discuss the challenges and opportunities associated with their usage as drug delivery systems.
人们一直在尝试通过设计创新的功能性药物递送系统（DDS）来实现合适的控释治疗系统。尽管已经开发出了各种类型的递送系统，但成功进入临床的策略却很少。由于其结构多样，沸石在控释和靶向药物递送方面引起了广泛的研究关注。沸石的结构可以是微孔、介孔或大孔的，可用于以可控方式将多种治疗剂递送至靶位点。在本综述中，我们介绍了不同类型的沸石，并讨论了将其用作药物递送系统所面临的挑战和机遇。
