Iowa State University, Department of Chemistry, US Department of Energy Ames Laboratory, Ames, IA 50011-3111, USA.
Expert Opin Drug Deliv. 2010 Sep;7(9):1013-29. doi: 10.1517/17425247.2010.498816.
The incorporation of stimuli-responsive properties into nanostructured systems has recently attracted significant attention in the research of intracellular drug/gene delivery. In particular, numerous surface-functionalized, end-capped mesoporous silica nanoparticle (MSN) materials have been designed as efficient stimuli-responsive controlled release systems with the advantageous 'zero premature release' property.
Herein, the most recent research progress on the design of biocompatible, capped MSN materials for stimuli-responsive intracellular controlled release of therapeutics and genes is reviewed. A series of hard and soft caps for drug encapsulation and a variety of internal and external stimuli for controlled release of different cargoes are summarized. Recent investigations on the biocompatibility of MSN both in vitro and in vivo are also discussed.
The reader will gain an understanding of the challenges for the future exploration of biocompatible stimuli-responsive MSN devices.
With a better understanding of the unique features of capped MSN and its behaviors in biological environment, these multifunctional materials will find a wide variety of applications in the field of drug/gene delivery.
刺激响应特性与纳米结构系统的结合，最近引起了细胞内药物/基因传递研究的极大关注。特别是，已经设计了许多表面功能化、端封的介孔硅纳米粒子（MSN）材料，作为具有有利的“零过早释放”特性的高效刺激响应控制释放系统。
本文综述了设计用于生物相容的、端封的 MSN 材料以实现治疗药物和基因的刺激响应细胞内控制释放的最新研究进展。总结了一系列用于药物封装的硬帽和软帽，以及用于不同载药的各种内外刺激的控制释放。还讨论了 MSN 在体外和体内的生物相容性的最新研究。
读者将了解生物相容的刺激响应 MSN 器件未来探索的挑战。
通过更好地了解端封 MSN 的独特特性及其在生物环境中的行为，这些多功能材料将在药物/基因传递领域得到广泛应用。
