Department of Thoracic and Cardiovascular Surgery, Huaihe Hospital of Henan University, China.
Department of Respiratory and Critical Care Medicine, Changzheng Hospital, Second Military Medical University, China.
J Photochem Photobiol B. 2020 Mar;204:111587. doi: 10.1016/j.jphotobiol.2019.111587. Epub 2019 Aug 9.
Although the photothermal therapy (PTT) has achieved tremendous progress in the recent times, still it has to improve an extensive way to achieve the efficient targeted photothermal removal of the tumor cells. Owing to this requirement, we demonstrated a novel class of reduced graphene oxide based photothermal therapeutic agent for the ablation of lung cancer cells (A549). A single step bio facile fabrication of graphene nanosheets using Memecylon edule leaf extract intermediated reduction of Graphene Oxide (GO). This process does not include the utilization of any toxic or harmful reducing agents. The relative results of different characterizations of graphene oxide and Memecylon edule leaf extract RGO delivers a potential representation by excluding the groups containing oxygen from GO and consecutive stabilization of the developed RGO. The reduced GO functionalization with the oxidized polyphenols results in their stability by avoiding the aggregation. The poly phenol anchored Reduced Graphene Oxide (RGO) exhibited exceptional near-infrared (NIR) irradiation of the lung cancer cells directed in vitro to deliver cytotoxicity. In an area of restricted success in the treatment of cancer, the results of our translation can provide a path for designing targeted PTT agents and also responds to stimulus environment for the safe ablation of the devastating disease.
尽管光热疗法（PTT）在最近取得了巨大的进展，但仍需要广泛改进才能实现高效的靶向光热肿瘤细胞消除。有鉴于此，我们开发了一种新型基于还原氧化石墨烯的光热治疗剂，用于消融肺癌细胞（A549）。采用 Memecylon edule 叶提取物介导的氧化石墨烯（GO）还原，一步简便地制备了石墨烯纳米片。该过程不包括使用任何有毒或有害的还原剂。GO 和 Memecylon edule 叶提取物 RGO 的不同特性的相对结果通过从 GO 中排除含氧基团并连续稳定开发的 RGO 提供了潜在的代表性。氧化多酚对还原氧化石墨烯（RGO）的功能化可避免聚集，从而实现其稳定性。聚多酚锚定的还原氧化石墨烯（RGO）在近红外（NIR）照射下对肺癌细胞具有非凡的靶向性，可在体外产生细胞毒性。在癌症治疗收效甚微的情况下，我们的研究结果可以为设计靶向 PTT 制剂提供途径，并对刺激环境做出响应，以安全消融这种破坏性疾病。
