Tani Akiyoshi, Seno Taisuke, Yokoyama Nozomu, Nakagawa Taisuke, Tomiyasu Hirotaka, Goto-Koshino Yuko, Tsujimoto Hajime, Ohno Koichi
Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1, Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan.
Veterinary Medical Center, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1, Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan.
J Vet Med Sci. 2020 Apr 9;82(4):437-440. doi: 10.1292/jvms.19-0560. Epub 2020 Feb 14.
Inflammatory colorectal polyps (ICRPs) are frequently observed in miniature dachshunds in Japan and treated by prednisolone and immunosuppressive drugs such as cyclosporine and leflunomide. The purpose of this retrospective study was to compare the treatment efficacy, such as response rate, response interval, recurrence rate, and adverse events between cyclosporine and leflunomide. While the response rates were significantly higher in dogs treated with leflunomide, no significant differences were observed in the response interval or recurrence rate. Two of the 11 dogs treated with leflunomide showed hematological or gastrointestinal adverse events, while no dog treated with cyclosporine showed any adverse events. A case-controlled prospective study to compare the treatment efficacy of leflunomide with that of cyclosporine should be conducted.
在日本，炎性大肠息肉（ICRPs）在迷你腊肠犬中经常被观察到，并使用泼尼松龙和环孢素、来氟米特等免疫抑制药物进行治疗。这项回顾性研究的目的是比较环孢素和来氟米特之间的治疗效果，如缓解率、缓解间隔、复发率和不良事件。虽然来氟米特治疗的犬只缓解率显著更高，但在缓解间隔或复发率方面未观察到显著差异。11只接受来氟米特治疗的犬中有2只出现血液学或胃肠道不良事件，而接受环孢素治疗的犬只未出现任何不良事件。应进行一项病例对照前瞻性研究，以比较来氟米特和环孢素的治疗效果。
