遵循高血压饮食防治计划（DASH）饮食模式可降低结直肠癌风险：系统评价和荟萃分析。
Adherence to the Dietary Approaches to Stop Hypertension (DASH) dietary pattern reduces the risk of colorectal cancer: A systematic review and meta-analysis.
机构信息
Students' Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran; Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, Iran.
Nutritionist, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
出版信息
Clin Nutr. 2020 Oct;39(10):2975-2981. doi: 10.1016/j.clnu.2020.02.002. Epub 2020 Feb 7.
BACKGROUND & AIMS: Colorectal cancer (CRC) has become a major concern due to industrialization and dietary changes generated by it. Many of the components of the DASH (Dietary Approach to Stop Hypertension) diet are associated with the risk of CRC. However, the relationship between DASH dietary pattern and CRC has not been studied yet in a systematic review and meta-analysis. The present study was conducted to review the studies investigating the relationship between DASH diet and the risk of CRC.
METHODS
PubMed and Scopus search engines were searched to find relevant publications from inception up to September 2019. All the observational studies that addressed the association between DASH diet and CRC were included in the systematic review and meta-analysis. All the steps including data base search, screening, and data extraction were carried out by two researchers, independently.
RESULTS
Eight studies included in this systematic review and 5 studies (out of 8 studies included in the systematic review) were included in the meta-analysis. Combining 12 effects sizes from 5 studies, a significant inverse association between adherence to the DASH diet and risk of CRC was found (RR: 0.80; 95% CI: 0.74, 0.85). Based on the result of this study, individuals with greater adherence to DASH diet had 20% lower risk of CRC.
CONCLUSION
The current study demonstrates that the risk of CRC is negatively associated with the adherence to the DASH dietary pattern.
背景与目的
由于工业化和由此产生的饮食变化，结直肠癌（CRC）已成为一个主要关注点。DASH（停止高血压的饮食方法）饮食的许多成分与 CRC 的风险相关。然而，DASH 饮食模式与 CRC 之间的关系尚未在系统评价和荟萃分析中进行研究。本研究旨在综述研究 DASH 饮食与 CRC 风险之间关系的研究。
方法
使用 PubMed 和 Scopus 搜索引擎从成立到 2019 年 9 月搜索相关文献。系统评价和荟萃分析纳入了所有探讨 DASH 饮食与 CRC 之间关联的观察性研究。所有步骤，包括数据库搜索、筛选和数据提取，均由两名研究人员独立进行。
结果
本系统评价纳入了 8 项研究，其中 5 项研究（来自系统评价纳入的 8 项研究）被纳入荟萃分析。综合 5 项研究的 12 个效应量，发现 DASH 饮食依从性与 CRC 风险之间呈显著负相关（RR：0.80；95%CI：0.74，0.85）。基于这项研究的结果，DASH 饮食依从性较高的个体 CRC 风险降低 20%。
结论
本研究表明，CRC 的风险与 DASH 饮食模式的依从性呈负相关。
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